1 00:00:00,000 --> 00:00:11,220 All right. So our next speaker is a longtime security malcontent, early adopter of the not-for-human consumption defense, 2 00:00:12,100 --> 00:00:19,680 and extensive research into the areas of cognition-enhancing drugs and lifestyle regimens will be the focus of his talk today. 3 00:00:21,560 --> 00:00:28,180 Presenting on neurogenic peptides, smart drugs, four-minute mile, here is Gingerbread. 4 00:00:28,540 --> 00:00:29,460 Thank you, sir. 5 00:00:33,360 --> 00:00:37,860 Can everybody hear me? Is that going to work? A little too close? Working? 6 00:00:38,060 --> 00:00:41,300 All right. Neurogenic peptides. 7 00:00:41,820 --> 00:00:48,860 So the reason I subtitled this smart drugs four-minute mile is that much like the four-minute mile, 8 00:00:49,000 --> 00:00:55,500 I think the pharmacological action behind this class of nootropic drugs will go from being the impossible feat 9 00:00:55,500 --> 00:00:58,640 that we set as something in the future that will never be reached, 10 00:00:58,760 --> 00:00:59,680 to the standard. 11 00:01:03,260 --> 00:01:07,300 Neurogenesis, the idea that you can grow more neurons, repair damaged neurons, 12 00:01:07,500 --> 00:01:12,580 actually increase the density of your brain, has long been considered impossible. 13 00:01:13,020 --> 00:01:17,820 The majority of nootropic drugs that we have now are more about augmenting the processes of the brain, 14 00:01:18,000 --> 00:01:20,300 much like tuning up a race car. 15 00:01:20,780 --> 00:01:23,780 Neurogenic peptides offer a novel approach. 16 00:01:24,040 --> 00:01:28,180 And what's really fun about the neurogenic peptides is after a period of experimentation, 17 00:01:28,600 --> 00:01:29,980 even if you completely change the process, you can still do it. 18 00:01:30,000 --> 00:01:32,020 You can completely cease any exposure to these drugs. 19 00:01:32,400 --> 00:01:34,260 The benefits persist. 20 00:01:34,920 --> 00:01:37,760 You'll, uh, so, let's just, let's go there. 21 00:01:37,940 --> 00:01:39,660 So, first things first. 22 00:01:40,180 --> 00:01:41,680 Haven't you seen me here before? 23 00:01:42,200 --> 00:01:44,860 Last year we gave a talk on nootropics here. 24 00:01:45,020 --> 00:01:47,440 We covered some more of the, uh, usual stuff. 25 00:01:48,140 --> 00:01:52,440 Um, I'm an infosec researcher and part-time pen tester out of Denver. 26 00:01:52,620 --> 00:01:54,840 I do a lot of independent security research. 27 00:01:54,980 --> 00:01:56,780 We do some pharmacological research. 28 00:01:57,460 --> 00:01:59,920 Uh, mostly looking at trends within the industry. 29 00:02:00,000 --> 00:02:06,400 Um, it's important to remember, though, that I am not a doctor, and I'm certainly not your doctor. 30 00:02:06,580 --> 00:02:12,680 So it's very important for you to do your own research, understand the mechanisms behind how these drugs work, 31 00:02:12,840 --> 00:02:15,820 and decide whether or not you're willing to take the risk. 32 00:02:16,000 --> 00:02:19,920 Because the one thing that is clear is this is not thoroughly researched. 33 00:02:20,240 --> 00:02:27,680 The mechanisms of these drugs are well understood, but their use in humans and especially their long-term use in healthy humans has not. 34 00:02:28,620 --> 00:02:29,980 So, throughout all of this, there's a lot of research being done. 35 00:02:29,980 --> 00:02:33,800 It seems that the same question keeps coming up over and over and over, and it is, 36 00:02:33,820 --> 00:02:35,520 Does it make me like you? 37 00:02:36,000 --> 00:02:40,500 And if I offer at least a little assurance that it won't, the conversation will move forward. 38 00:02:41,340 --> 00:02:46,320 So, in order to give credit where it's due, we have to talk about Rita Levi-Montalcini. 39 00:02:46,780 --> 00:02:50,360 Please, please look into this woman's history. It's a fascinating story. 40 00:02:50,640 --> 00:02:56,720 She was the first Nobel laureate to reach a hundred, and she was the oldest still productive Nobel laureate to date. 41 00:02:56,940 --> 00:02:59,960 At a hundred and two, she was still releasing papers. 42 00:02:59,960 --> 00:03:03,840 That are every bit as lucid and relevant as papers from her twenties. 43 00:03:04,500 --> 00:03:10,120 In fact, there's a famous interview I like to reference where she's doing an interview with Italian television. 44 00:03:10,500 --> 00:03:14,060 And they say, you know, Montalcini, do you feel that you've slowed down? 45 00:03:14,180 --> 00:03:16,680 Do you feel that these new scientists can out-think you? 46 00:03:16,940 --> 00:03:19,900 And she just got a little sparkle in her eye and smiled to him. 47 00:03:19,980 --> 00:03:23,960 She's like, oh, no, no, no. I'm just as lucid as I was in my twenties. 48 00:03:24,160 --> 00:03:29,060 The only difference is I have an entire lifetime of experience and training to draw upon. 49 00:03:29,060 --> 00:03:31,760 She's like, I do take more naps though. 50 00:03:33,060 --> 00:03:36,780 So she absolutely should be honored for these discoveries. 51 00:03:36,980 --> 00:03:40,700 She should be referenced in a lot of this stuff because if it weren't for her observations 52 00:03:40,700 --> 00:03:47,000 and her deduction of the mechanism behind her observations, we wouldn't have this area of research. 53 00:03:47,380 --> 00:03:55,320 So working with Stanley Cohen in the fifties, they were able to isolate NGF from tumor cells. 54 00:03:55,640 --> 00:03:58,900 She had noticed that oftentimes with certain forms of tumors, 55 00:03:59,060 --> 00:04:02,680 you will have great bundles of nerve tissue. 56 00:04:02,860 --> 00:04:06,580 You'll have innervated masses that just swarm and wrap the tumors. 57 00:04:06,800 --> 00:04:14,120 And from looking very carefully, she was able to determine that while the neurons had invaded most tissues, 58 00:04:14,260 --> 00:04:19,920 the veins, the muscles that had invaded most tissues, it did not invade the arteries. 59 00:04:20,220 --> 00:04:25,560 And so she deduced that perhaps this action was coming from something the tumors were releasing. 60 00:04:25,980 --> 00:04:27,760 And from that deduction, 61 00:04:27,760 --> 00:04:31,680 she was able to isolate NGF, Neurogenic Growth Factor. 62 00:04:31,860 --> 00:04:35,160 Now this is a peptide, a string of amino acids, 63 00:04:36,260 --> 00:04:43,200 that is responsible for a lot of neuron-based processes within the body. 64 00:04:43,340 --> 00:04:46,840 Certainly in learning and in early childhood development, 65 00:04:47,780 --> 00:04:54,700 NGF is now being researched and is a large part behind the attempted head transplant that is going on now. 66 00:04:54,780 --> 00:04:57,480 If it weren't for NGF and the ability for, 67 00:04:57,760 --> 00:05:01,380 the stimulation of neuron growth, none of that would be possible. 68 00:05:01,660 --> 00:05:07,040 But it took 30 years for the discovery to be recognized. 69 00:05:07,280 --> 00:05:11,360 It wasn't until 1986 that they were awarded the Nobel Prize. 70 00:05:11,760 --> 00:05:14,100 But what was great, and is kind of telling, 71 00:05:14,240 --> 00:05:16,940 is the individuals on the research team knew what they had. 72 00:05:17,080 --> 00:05:20,820 And more than one began immediately administering the drug to themselves. 73 00:05:21,320 --> 00:05:25,300 In fact, Montalcini famously constructed eye drops 74 00:05:25,300 --> 00:05:27,680 and would administer NGF to the eye, 75 00:05:27,760 --> 00:05:30,460 daily, and sometimes multiple times daily, 76 00:05:30,580 --> 00:05:33,420 for the rest of her life, shortly following the discovery. 77 00:05:34,640 --> 00:05:37,340 That's why I give her credit as a gonzo scientist here. 78 00:05:37,440 --> 00:05:40,360 Because, you know, long before she would ever get any kind of approval, 79 00:05:40,480 --> 00:05:42,200 she's like, mm-mm, it's for me. 80 00:05:42,960 --> 00:05:48,940 Now if you were to hire a peptide lab to produce human Neurogenic Growth Factor, 81 00:05:48,960 --> 00:05:52,440 in a quality that was sufficient to put in your eye safely, 82 00:05:52,720 --> 00:05:56,080 you're looking at roughly $10,000 a month per person. 83 00:05:56,080 --> 00:06:00,380 So, unless you're a biochemist, it's a little bit prohibitive. 84 00:06:01,940 --> 00:06:07,880 So, the drugs we're working on here are sort of a shortcut. 85 00:06:08,240 --> 00:06:13,920 They allow your body to release more NGF, or BDNF, or GCNF, 86 00:06:14,040 --> 00:06:19,330 or, I know, or GCNF, or BDNF. 87 00:06:19,660 --> 00:06:23,520 And some of these act as prodrugs for these same compounds. 88 00:06:23,700 --> 00:06:24,980 But considering they're proteins, 89 00:06:24,980 --> 00:06:28,680 the vast majority of these compounds are very fragile. 90 00:06:28,840 --> 00:06:32,060 And so, even prodrug formation is not an option. 91 00:06:32,800 --> 00:06:38,000 So, brain-derived nootrophic factor is probably the most active of this group. 92 00:06:38,620 --> 00:06:43,540 You see a line of nootropic drugs that are being released, 93 00:06:43,600 --> 00:06:45,520 such as Lion's Mane extract. 94 00:06:45,860 --> 00:06:49,200 The herinesions and erinesions within the extract 95 00:06:49,660 --> 00:06:53,360 is shown to release this type of drug within the body. 96 00:06:53,360 --> 00:06:58,600 Now, nerve growth factor, of course, was the topic of Montalcini's original research. 97 00:06:58,900 --> 00:07:03,180 And CNTF is interesting in that it promotes the survival of neurons 98 00:07:03,180 --> 00:07:05,240 much more than any kind of expansion. 99 00:07:07,240 --> 00:07:12,900 CNTF is capable of promoting the survival of dopamine neurons, 100 00:07:13,060 --> 00:07:15,320 even in situations where they normally would be destroyed. 101 00:07:15,580 --> 00:07:20,260 And so, they've been able to show it have a prophylactic effect against head injury. 102 00:07:20,900 --> 00:07:23,200 They've been using it for ischemic victims, 103 00:07:23,360 --> 00:07:27,220 and there's a lot of research that shows 104 00:07:27,220 --> 00:07:30,960 that we have just scratched the surface of the use of these compounds. 105 00:07:31,440 --> 00:07:33,180 Particularly in the United States, 106 00:07:33,320 --> 00:07:37,560 our understanding of and our utilization of peptide-based pharmacology 107 00:07:37,560 --> 00:07:39,100 is in its infancy. 108 00:07:39,340 --> 00:07:42,560 We've absolutely been outshined by the rest of the world, 109 00:07:42,600 --> 00:07:44,680 and in particular, the former Soviet Union. 110 00:07:47,040 --> 00:07:48,400 So, it sounds easy, right? 111 00:07:48,820 --> 00:07:50,740 More brain, more better. 112 00:07:51,300 --> 00:07:53,100 Everyone would like to just be able to 113 00:07:53,360 --> 00:07:56,140 have a dome head and fit as much brain in there as you can afford. 114 00:07:56,260 --> 00:07:56,940 It's not a big deal. 115 00:07:57,460 --> 00:08:01,460 But the structure of the brain is what provides its magic, 116 00:08:01,680 --> 00:08:02,720 not the substance. 117 00:08:03,160 --> 00:08:05,400 And having undifferentiated brain tissue 118 00:08:05,400 --> 00:08:07,840 exploding with growth inside of your head 119 00:08:07,840 --> 00:08:09,880 is not necessarily a constructive thing. 120 00:08:10,420 --> 00:08:14,240 So, if you have a predisposition or a family history 121 00:08:14,240 --> 00:08:16,360 for any type of organic brain disease, 122 00:08:16,660 --> 00:08:20,840 it would be best to just sort of write off this line of experimentation. 123 00:08:22,620 --> 00:08:26,820 Having half of your brain soaked up with some useless tissue 124 00:08:26,820 --> 00:08:27,760 is not going to be good. 125 00:08:29,520 --> 00:08:33,020 So, there have been some drugs developed in this space, 126 00:08:33,240 --> 00:08:35,460 particularly in the Soviet Union, as we said. 127 00:08:35,820 --> 00:08:40,180 So, the first were products of the state. 128 00:08:40,400 --> 00:08:42,020 And so, what does the state do? 129 00:08:42,200 --> 00:08:45,040 They look to agricultural byproducts for their needs. 130 00:08:45,280 --> 00:08:48,880 And so, one of the first readily available sources of these peptides 131 00:08:48,880 --> 00:08:50,820 was in pig brain concentrates. 132 00:08:50,840 --> 00:08:52,700 And exactly as it sounds, 133 00:08:52,800 --> 00:08:57,100 the brains from recently deceased pigs were harvested, purified, 134 00:08:57,280 --> 00:08:59,600 and sold as a drug called cerebrolysin. 135 00:08:59,780 --> 00:09:02,320 You can actually still purchase cerebrolysin. 136 00:09:02,400 --> 00:09:04,200 It's totally unregulated in the United States. 137 00:09:04,400 --> 00:09:05,840 It's kind of fallen out of favor 138 00:09:05,840 --> 00:09:08,580 as some of these more advanced drugs have become available. 139 00:09:08,800 --> 00:09:10,360 But it absolutely is effective. 140 00:09:10,720 --> 00:09:12,200 And unlike some of the others, 141 00:09:12,320 --> 00:09:15,860 there are anecdotal reports of people with 20 years of daily administration. 142 00:09:16,360 --> 00:09:20,540 And so, that can... 143 00:09:20,540 --> 00:09:23,120 That can be a real low-hanging fruit if you want to get started. 144 00:09:23,280 --> 00:09:26,120 It's absolutely the one with the most safety profile. 145 00:09:27,240 --> 00:09:32,480 Now, after looking to these concentrates and proving their efficacy, 146 00:09:32,840 --> 00:09:34,500 they're able, through clinical trials, 147 00:09:34,560 --> 00:09:37,400 to determine which portions of this protein amalgam 148 00:09:37,400 --> 00:09:40,720 was actually providing the neurological action. 149 00:09:41,120 --> 00:09:43,500 And so, after the brain concentrates, 150 00:09:43,500 --> 00:09:45,840 we start to get into these structured peptide drugs. 151 00:09:46,240 --> 00:09:50,080 And so, this is the group that most people are going to be familiar with. 152 00:09:50,760 --> 00:09:53,700 Nupept, this particular drug, very, very cheap, 153 00:09:53,800 --> 00:09:57,120 extremely potent in just dozens of milligrams per dosage. 154 00:09:57,340 --> 00:10:01,500 But Nupept is fairly unique within the family 155 00:10:01,500 --> 00:10:03,220 in that it can be stored at room temperature 156 00:10:03,220 --> 00:10:05,160 and can be administered orally. 157 00:10:05,280 --> 00:10:09,440 The vast majority of these drugs are too fragile to be administered orally. 158 00:10:09,540 --> 00:10:10,500 They have to be injected. 159 00:10:10,780 --> 00:10:13,340 And that was a reason why up until recently, 160 00:10:13,400 --> 00:10:15,000 and with recent advancements, 161 00:10:15,280 --> 00:10:17,180 their popularity had been limited. 162 00:10:17,320 --> 00:10:19,520 There's quite a stigma with needle-based 163 00:10:20,540 --> 00:10:22,660 and recreational drug administration here in the U.S. 164 00:10:24,440 --> 00:10:27,920 So, Solonc has been marketed in Europe 165 00:10:27,920 --> 00:10:31,380 and in the former Soviet Union for almost 20 years now. 166 00:10:31,600 --> 00:10:32,800 It's over the counter. 167 00:10:32,960 --> 00:10:34,500 It's used as an anxiolytic. 168 00:10:34,660 --> 00:10:36,340 So, these protein-based drugs, 169 00:10:36,460 --> 00:10:40,600 despite their seemingly fragile pharmacology, 170 00:10:40,720 --> 00:10:43,840 have every bit the efficacy of alkaloids 171 00:10:43,840 --> 00:10:46,620 and other more traditional pharmacological agents. 172 00:10:47,060 --> 00:10:48,920 Solonc has an anxiolytic potential 173 00:10:48,920 --> 00:10:50,520 on par with low-dose drugs. 174 00:10:50,540 --> 00:10:51,680 Low-dose benzodiazepines. 175 00:10:52,100 --> 00:10:55,780 Absolutely very, very powerful sedative 176 00:10:55,780 --> 00:10:59,480 without having the ceiling with sedation. 177 00:10:59,680 --> 00:11:02,300 You can dose yourself with a hundred times 178 00:11:02,300 --> 00:11:03,900 the recommended dose of Solonc 179 00:11:03,900 --> 00:11:05,760 and you're not going to have an adverse health event. 180 00:11:06,120 --> 00:11:09,680 Now, C-Max is probably the most popular drug. 181 00:11:09,880 --> 00:11:12,420 This was developed, again, in the former Soviet Union. 182 00:11:12,620 --> 00:11:15,460 And their government had, for whatever reason, 183 00:11:15,600 --> 00:11:18,180 an emphasis on cognitive decline research. 184 00:11:18,500 --> 00:11:20,460 Some have speculated that it's because 185 00:11:20,540 --> 00:11:23,780 of alcoholism or nutritional deficiencies 186 00:11:23,780 --> 00:11:24,500 or what have you. 187 00:11:24,600 --> 00:11:27,420 But they absolutely have invested more time, 188 00:11:27,460 --> 00:11:29,660 more research, and more money 189 00:11:29,660 --> 00:11:31,120 than the United States has 190 00:11:31,120 --> 00:11:33,720 in maintaining the cognition of its populace. 191 00:11:33,940 --> 00:11:37,280 So, C-Max is a potent nootropic drug. 192 00:11:37,440 --> 00:11:38,380 Very potent. 193 00:11:38,700 --> 00:11:42,840 The action is within just moments after administration. 194 00:11:43,400 --> 00:11:46,020 Very similar to some of the racetam drugs 195 00:11:46,020 --> 00:11:47,260 in a clearing of vision, 196 00:11:47,500 --> 00:11:49,020 slight stimulation, 197 00:11:49,020 --> 00:11:50,400 verbal fluidity, 198 00:11:50,540 --> 00:11:51,320 memory. 199 00:11:51,740 --> 00:11:54,640 And these effects will last five, six hours. 200 00:11:54,880 --> 00:11:58,240 Again, because of the sort of ephemeral nature 201 00:11:58,240 --> 00:11:59,460 of these protein drugs, 202 00:11:59,760 --> 00:12:03,020 you could administer a hundred times the active dose 203 00:12:03,020 --> 00:12:05,520 and not necessarily have an adverse event. 204 00:12:06,300 --> 00:12:08,600 And the most adverse events are discomfort. 205 00:12:08,960 --> 00:12:12,240 You know, other than the sort of atypical anaphylaxis 206 00:12:12,240 --> 00:12:13,000 that you may see, 207 00:12:13,880 --> 00:12:15,340 these drugs are incredibly, 208 00:12:15,640 --> 00:12:18,260 or sorry, have an incredibly wide therapeutic window. 209 00:12:19,020 --> 00:12:24,220 So, C-Max has been marketed in the United States, 210 00:12:24,400 --> 00:12:26,680 but because of its ejection only administration, 211 00:12:27,100 --> 00:12:28,540 it really never caught on. 212 00:12:28,780 --> 00:12:32,860 And so, there were various attempts to try and make C-Max 213 00:12:32,860 --> 00:12:35,040 more bioavailable. 214 00:12:35,260 --> 00:12:37,600 And some of those, those adjustments 215 00:12:37,600 --> 00:12:39,740 were the second wave. 216 00:12:41,500 --> 00:12:42,140 No! 217 00:12:42,920 --> 00:12:44,500 None of that, thank you. 218 00:12:45,060 --> 00:12:47,680 So, nice try, that was good. 219 00:12:47,680 --> 00:12:53,300 So, we get into these structured drugs, 220 00:12:56,100 --> 00:12:59,740 that the structures have been modified 221 00:12:59,740 --> 00:13:04,340 specifically to provide the action they want. 222 00:13:04,860 --> 00:13:10,040 Now, N-acetyl C-Max was created as sort of a protection 223 00:13:10,040 --> 00:13:12,780 against the degradation of this peptide. 224 00:13:12,880 --> 00:13:15,940 Instead of having to be stored entirely under refrigeration, 225 00:13:15,980 --> 00:13:17,660 it administered with subcutaneous, 226 00:13:17,680 --> 00:13:18,260 subcutaneous injection, 227 00:13:18,580 --> 00:13:21,560 N-acetyl C-Max can be administered intranasally. 228 00:13:21,780 --> 00:13:23,100 And so, all of a sudden, 229 00:13:23,140 --> 00:13:25,880 a whole group of people that would never just inject things 230 00:13:25,880 --> 00:13:27,320 under their skin for fun, 231 00:13:27,420 --> 00:13:28,940 had access to it. 232 00:13:29,160 --> 00:13:32,300 Now, N-acetyl C-Max also can be stored at room temperature 233 00:13:32,300 --> 00:13:34,780 for periods of, you know, 40 hours or so, 234 00:13:34,880 --> 00:13:36,220 and still be safe. 235 00:13:36,360 --> 00:13:38,600 So, that allows a whole window of clinical administration 236 00:13:38,600 --> 00:13:42,720 without the refrigerators and various things like, 237 00:13:42,760 --> 00:13:43,720 that are needed. 238 00:13:43,900 --> 00:13:46,740 Now, N-acetyl C-Max Amidate is different. 239 00:13:47,680 --> 00:13:51,000 N-acetyl C-Max Amidate was created with the same goal in mind, 240 00:13:51,060 --> 00:13:52,880 to make it more bioavailable, more stable. 241 00:13:53,120 --> 00:13:55,860 But instead of being created by a pharmaceutical company, 242 00:13:56,020 --> 00:13:58,360 these were created by people in the nootropic space. 243 00:13:58,820 --> 00:14:00,460 This was created by individuals, 244 00:14:00,760 --> 00:14:03,760 really with not the necessary training. 245 00:14:03,920 --> 00:14:06,480 There haven't been any clinical studies done, 246 00:14:06,680 --> 00:14:08,400 but there are tons of anecdotal reports. 247 00:14:08,900 --> 00:14:12,140 And both the acetylation and the Amidate 248 00:14:12,140 --> 00:14:14,120 make the drugs much more potent. 249 00:14:14,320 --> 00:14:16,580 As you would expect, if it was more bioavailable, 250 00:14:16,780 --> 00:14:17,660 the same dose would be used. 251 00:14:17,660 --> 00:14:19,040 The dosage is going to provide more action. 252 00:14:19,280 --> 00:14:21,100 But also, because they're more stable, 253 00:14:21,180 --> 00:14:24,440 you see longer durations of action for these drugs. 254 00:14:25,080 --> 00:14:27,840 N-acetyl C-Max is very stimulatory. 255 00:14:28,080 --> 00:14:30,920 You can be completely worn out, 256 00:14:30,940 --> 00:14:32,780 ready to go to bed and have a dosage 257 00:14:32,780 --> 00:14:36,180 and be awake as if you had used a more traditional stimulant. 258 00:14:36,400 --> 00:14:38,680 Again, the dosage window is incredibly broad. 259 00:14:38,900 --> 00:14:40,200 You're not going to have these sort of 260 00:14:41,040 --> 00:14:42,280 overstimulation adverse effects, 261 00:14:42,380 --> 00:14:44,000 and you don't really develop a tolerance. 262 00:14:44,620 --> 00:14:46,480 There's individuals who have been using this drug 263 00:14:46,480 --> 00:14:48,680 for about five years now, since it was invented, 264 00:14:48,820 --> 00:14:50,540 or at least distributed to the public. 265 00:14:50,740 --> 00:14:53,840 And again, they say no development of tolerance, 266 00:14:53,960 --> 00:14:56,260 even with somewhat less than responsible use. 267 00:14:56,660 --> 00:15:04,820 So, that brings us to where we kind of are at today. 268 00:15:05,140 --> 00:15:07,060 We're getting to the point where individuals 269 00:15:07,060 --> 00:15:09,520 who are operating in this space with no oversight 270 00:15:09,520 --> 00:15:11,560 are being provided with the resources 271 00:15:11,560 --> 00:15:13,540 to push this research forward, 272 00:15:13,780 --> 00:15:15,040 but without the... 273 00:15:16,560 --> 00:15:19,180 institutions of traditional pharmaceutical research. 274 00:15:19,600 --> 00:15:23,560 So, what we're having are people reading mice studies. 275 00:15:23,820 --> 00:15:26,660 We have people that are looking at animal-based reports, 276 00:15:26,900 --> 00:15:29,200 and they're extrapolating that research 277 00:15:29,200 --> 00:15:30,640 and producing a drug, 278 00:15:30,880 --> 00:15:33,300 getting it out to the world to the lowest bidder, 279 00:15:33,400 --> 00:15:36,440 and then distributing it wholesale to the greedy public. 280 00:15:36,760 --> 00:15:38,880 And so, we have drugs not only like 281 00:15:38,880 --> 00:15:41,260 the N-acetyl C-Max Amidate, but P21. 282 00:15:41,620 --> 00:15:44,920 This isn't just a more bioavailable alteration 283 00:15:44,920 --> 00:15:46,360 to an already tested drug. 284 00:15:46,480 --> 00:15:48,300 This is a peptide sequence 285 00:15:48,300 --> 00:15:51,260 shown to have efficacy in animal studies, 286 00:15:51,440 --> 00:15:54,920 and then 20 years go by, 287 00:15:55,160 --> 00:15:57,680 some individual with a peptide-based 288 00:15:57,680 --> 00:15:59,880 nootropics company in the U.S. sees it, 289 00:15:59,940 --> 00:16:01,960 has it developed, and starts distributing it 290 00:16:01,960 --> 00:16:04,620 to people with a not-for-human-consumption caveat. 291 00:16:05,120 --> 00:16:07,720 So, there seems to be quite a 292 00:16:07,720 --> 00:16:09,480 almost institutional naivete 293 00:16:10,040 --> 00:16:13,240 that has pervaded the nootropics scene. 294 00:16:13,400 --> 00:16:15,980 These aren't necessarily your traditional drug people 295 00:16:15,980 --> 00:16:18,560 that are used to not trusting their suppliers. 296 00:16:18,960 --> 00:16:22,560 And so, there's a lot of room for problems. 297 00:16:22,820 --> 00:16:25,580 And so, I think that before this is all said and done, 298 00:16:25,760 --> 00:16:27,440 perhaps not with the peptide drugs, 299 00:16:27,600 --> 00:16:29,640 but the nootropics industry is certainly 300 00:16:29,640 --> 00:16:30,900 going to have a wake-up call, 301 00:16:31,040 --> 00:16:33,960 as people are becoming more and more bold, 302 00:16:34,040 --> 00:16:35,280 and more and more products, 303 00:16:35,360 --> 00:16:38,940 which have never been tested in primates, 304 00:16:38,940 --> 00:16:41,040 let alone humans, are just being released, 305 00:16:41,140 --> 00:16:42,780 and people are taking them each and every day. 306 00:16:43,320 --> 00:16:44,920 Something that I think is important to remember, 307 00:16:44,920 --> 00:16:46,340 even with this class of drugs are, 308 00:16:46,420 --> 00:16:48,540 there is no biochemical-free lunch. 309 00:16:49,000 --> 00:16:50,900 There's nothing you're going to be able to do 310 00:16:50,900 --> 00:16:52,860 each and every day that is not going to have 311 00:16:52,860 --> 00:16:54,360 a lasting effect on your body, 312 00:16:54,440 --> 00:16:57,080 or isn't going to down-regulate in some way. 313 00:16:57,480 --> 00:17:00,180 Now, I know that's kind of contrary to the 314 00:17:00,180 --> 00:17:02,080 you aren't going to develop a tolerance, 315 00:17:02,360 --> 00:17:04,120 but that's based more on broad experience 316 00:17:04,440 --> 00:17:06,440 than this particular class of drugs. 317 00:17:07,340 --> 00:17:10,540 So, delta-sleep-inducing peptide is an interesting one 318 00:17:10,540 --> 00:17:12,100 that's only recently become available 319 00:17:12,100 --> 00:17:13,760 outside of research markets, 320 00:17:13,760 --> 00:17:15,860 and it's been shown in rodent studies 321 00:17:15,860 --> 00:17:18,980 to induce spindle forms on EEGs 322 00:17:19,720 --> 00:17:21,960 with, almost as soon as it's induced. 323 00:17:22,260 --> 00:17:23,620 And so they're looking at this, 324 00:17:23,660 --> 00:17:25,420 using it for a deep restorative sleep, 325 00:17:25,560 --> 00:17:27,340 or for people to use it to consolidate memories. 326 00:17:28,900 --> 00:17:30,080 Again, anecdotal only. 327 00:17:30,300 --> 00:17:32,200 This has never been tested in humans, 328 00:17:32,360 --> 00:17:34,760 and you certainly couldn't stretch it 329 00:17:34,760 --> 00:17:35,740 to say things are safe. 330 00:17:36,000 --> 00:17:38,880 Now, apitilon is really unique here, 331 00:17:39,000 --> 00:17:39,980 and I'd like to mention it, 332 00:17:40,020 --> 00:17:41,120 because unlike the others, 333 00:17:41,260 --> 00:17:43,740 this one has an action on us, 334 00:17:44,400 --> 00:17:44,880 telomerase. 335 00:17:45,580 --> 00:17:48,220 Telomeres at the end of your genetic material 336 00:17:48,220 --> 00:17:50,680 that help sort of soup up the damage 337 00:17:50,680 --> 00:17:52,860 that has happened to your DNA over time, 338 00:17:53,060 --> 00:17:54,420 shorten and shorten. 339 00:17:54,640 --> 00:17:57,420 And there's some pretty strong correlation 340 00:17:57,420 --> 00:18:01,100 between telomere length and the overall age of an animal, 341 00:18:01,180 --> 00:18:02,420 or at least how well it's aging. 342 00:18:02,620 --> 00:18:04,620 And so this is one of the very few drugs 343 00:18:04,620 --> 00:18:06,760 that has been shown to interact with telomeres 344 00:18:06,760 --> 00:18:09,500 without just inducing tumor growth immediately. 345 00:18:09,880 --> 00:18:11,840 Because as you know, keeping cells alive 346 00:18:11,840 --> 00:18:13,740 after they don't want to be alive, 347 00:18:13,760 --> 00:18:16,380 is not necessarily a constructive thing to do. 348 00:18:16,680 --> 00:18:20,000 So again, within the nootropics industry, 349 00:18:20,240 --> 00:18:22,520 they have made acetylated and amidate versions. 350 00:18:22,840 --> 00:18:25,240 And these drugs are pretty cheap, 351 00:18:25,280 --> 00:18:26,640 all things considered. 352 00:18:28,200 --> 00:18:31,420 There are suppliers that are domestic within the U.S. 353 00:18:31,480 --> 00:18:34,760 that are producing the proteins within the U.S., 354 00:18:34,760 --> 00:18:37,320 and so there's a certain degree of safety 355 00:18:37,320 --> 00:18:38,620 that people think is assumed 356 00:18:38,620 --> 00:18:41,620 because of the broad dosage windows and what have you. 357 00:18:41,660 --> 00:18:43,740 But these drugs are absolutely untenable. 358 00:18:43,760 --> 00:18:43,940 They are tested, 359 00:18:44,020 --> 00:18:46,000 and it's important to keep that in mind throughout. 360 00:18:48,180 --> 00:18:49,400 So I want to give us a little, 361 00:18:49,480 --> 00:18:50,760 some time for questions here. 362 00:18:50,880 --> 00:18:52,420 So if anyone wants to get a hold of me, 363 00:18:52,500 --> 00:18:53,580 here's the information. 364 00:18:53,960 --> 00:18:55,220 I just want you all to remember, 365 00:18:55,780 --> 00:18:56,580 only users, 366 00:18:56,860 --> 00:18:57,320 or sorry, 367 00:18:57,480 --> 00:18:59,140 only losers use drugs. 368 00:19:03,140 --> 00:19:03,880 All right. 369 00:19:05,220 --> 00:19:06,240 Go use the mic, man. 370 00:19:08,080 --> 00:19:09,080 Unless you want to shout. 371 00:19:09,880 --> 00:19:10,380 Thank you. 372 00:19:21,640 --> 00:19:24,560 What do you take of all these things, if any? 373 00:19:25,140 --> 00:19:26,780 What do I think, or what do I take? 374 00:19:26,920 --> 00:19:27,260 What do you take? 375 00:19:27,900 --> 00:19:30,100 I'm not taking any at this time, 376 00:19:30,240 --> 00:19:33,200 but I think if you were going to choose just one, 377 00:19:33,300 --> 00:19:35,900 if you had to pick just one to experiment with, 378 00:19:36,080 --> 00:19:37,280 it would be C-Max. 379 00:19:37,520 --> 00:19:41,660 C-Max has had hundreds of millions of individual doses 380 00:19:41,660 --> 00:19:43,320 administered to individual people, 381 00:19:43,460 --> 00:19:43,740 and it's a very, very good drug. 382 00:19:43,760 --> 00:19:47,280 And it has a very broad window of action. 383 00:19:47,440 --> 00:19:49,660 So I personally enjoy it. 384 00:19:49,660 --> 00:19:52,660 I think it's a better stimulant than caffeine. 385 00:19:52,880 --> 00:19:54,340 It's much easier on your system. 386 00:19:54,540 --> 00:19:57,680 And should you administer some and then need to go to sleep, 387 00:19:57,780 --> 00:19:58,960 it's absolutely possible. 388 00:19:59,400 --> 00:20:00,400 And so C-Max, 389 00:20:00,700 --> 00:20:04,600 you're looking at about $60 to $70 per person per month. 390 00:20:04,720 --> 00:20:07,180 So it's not necessarily a cheap choice, 391 00:20:07,380 --> 00:20:09,480 and it has to be stored under refrigeration 392 00:20:09,480 --> 00:20:12,320 unless you buy some of the newer modified versions. 393 00:20:13,040 --> 00:20:13,660 All right. 394 00:20:14,520 --> 00:20:15,360 Anything else? 395 00:20:15,500 --> 00:20:17,000 Any questions for the microphone? 396 00:20:18,380 --> 00:20:20,840 What do you think about the administration in the nasal? 397 00:20:20,980 --> 00:20:23,860 Because, like, C-Max and some of them go nasal, 398 00:20:23,940 --> 00:20:25,500 and there's the injection as well. 399 00:20:25,740 --> 00:20:28,720 Oh, I absolutely think that the pharmacology is distinct. 400 00:20:29,500 --> 00:20:33,300 Intranasal administration produces different results 401 00:20:33,300 --> 00:20:35,120 than subcutaneous administration. 402 00:20:35,640 --> 00:20:37,720 And so there are some researchers 403 00:20:37,720 --> 00:20:39,480 and certainly nootropics enthusiasts 404 00:20:39,480 --> 00:20:41,620 that prefer intranasal administration. 405 00:20:42,080 --> 00:20:43,740 But for me, 406 00:20:43,760 --> 00:20:45,640 and this was the horrible caveat 407 00:20:45,640 --> 00:20:48,260 that kept me from actually using C-Max long term, 408 00:20:48,400 --> 00:20:50,120 is it produced anosmia, 409 00:20:50,300 --> 00:20:52,020 like very strong anosmia. 410 00:20:52,240 --> 00:20:56,300 I had no sense of smell for probably four months 411 00:20:56,300 --> 00:20:57,880 after I had stopped entirely. 412 00:20:58,180 --> 00:20:59,120 And I could smell coffee, 413 00:20:59,200 --> 00:21:00,020 I could smell food, 414 00:21:00,160 --> 00:21:02,200 but, like, real subtle biological odors, 415 00:21:02,220 --> 00:21:03,360 like I couldn't smell my wife, 416 00:21:03,440 --> 00:21:05,720 I couldn't tell if my kids were in the room. 417 00:21:05,860 --> 00:21:07,700 It was disturbing enough 418 00:21:07,700 --> 00:21:10,560 to not warrant any further experimentation. 419 00:21:11,000 --> 00:21:12,780 So I've spoken with other researchers 420 00:21:12,780 --> 00:21:14,100 who haven't had that problem, 421 00:21:14,300 --> 00:21:15,840 but it was enough to scare me off. 422 00:21:18,400 --> 00:21:19,160 What are you doing, brother? 423 00:21:19,500 --> 00:21:20,380 Just a question. 424 00:21:21,240 --> 00:21:24,440 Speaking of the adrenasiums and the henrasiums, 425 00:21:25,140 --> 00:21:27,640 have you done any research into the other 426 00:21:27,640 --> 00:21:30,740 supposed fungal families that have been shown 427 00:21:30,740 --> 00:21:32,900 to regrow neuron growth? 428 00:21:32,900 --> 00:21:33,380 Oh, yeah. 429 00:21:33,840 --> 00:21:34,460 Oh, yeah. 430 00:21:34,540 --> 00:21:35,280 Should I email you? 431 00:21:35,540 --> 00:21:36,960 Please do. 432 00:21:37,160 --> 00:21:37,320 Okay. 433 00:21:37,520 --> 00:21:39,640 In fact, certain strains of reishi, 434 00:21:39,820 --> 00:21:41,040 particularly the red reishi, 435 00:21:41,140 --> 00:21:41,960 have been shown to be 436 00:21:41,960 --> 00:21:45,620 even more potent releasers of NGF and BDNF. 437 00:21:45,800 --> 00:21:48,340 And so some of the issues that you have 438 00:21:48,340 --> 00:21:51,000 with high-dose BDNF and NGF supplementation, 439 00:21:51,000 --> 00:21:53,300 or at least, you know, excretalogue supplementation, 440 00:21:53,300 --> 00:21:56,880 is that you'll begin to get formication with high doses. 441 00:21:57,040 --> 00:21:59,060 You'll have ant-crawling sensation 442 00:21:59,060 --> 00:22:01,140 or tingles over your head and on your skin, 443 00:22:01,280 --> 00:22:03,620 and that can be a sign that you're overdoing it. 444 00:22:03,680 --> 00:22:06,780 But again, there's still even further nootropic action 445 00:22:06,780 --> 00:22:09,240 once you've, you know, become accustomed to that. 446 00:22:09,640 --> 00:22:11,320 The NGF... 447 00:22:11,320 --> 00:22:12,680 The aronesians... 448 00:22:12,680 --> 00:22:13,060 No! 449 00:22:14,660 --> 00:22:16,840 The lion's mane mushroom extracts, 450 00:22:16,840 --> 00:22:18,660 specifically the aronesians and hernesiones, 451 00:22:18,920 --> 00:22:22,840 are, again, shown to provide long-lasting effects 452 00:22:22,840 --> 00:22:23,820 even after you stop. 453 00:22:24,040 --> 00:22:26,420 If you take it for a year and this is how you feel, 454 00:22:26,540 --> 00:22:27,980 that's pretty much how you're going to stay, 455 00:22:28,180 --> 00:22:30,520 which is highly distinct from the racetams, 456 00:22:30,660 --> 00:22:33,840 which constantly are reaching into different plateaus of action 457 00:22:33,840 --> 00:22:36,900 and then stepping back down without any real changes. 458 00:22:37,580 --> 00:22:39,620 So, yeah, I would... 459 00:22:39,620 --> 00:22:41,220 The formication thing, 460 00:22:41,300 --> 00:22:42,260 is a bit of an issue, 461 00:22:42,460 --> 00:22:44,800 and we've spoken with individuals who have said 462 00:22:44,800 --> 00:22:47,960 that with high-dose supplementation of NGF and BDNF substances, 463 00:22:48,340 --> 00:22:51,320 they've overwritten their childhood memories, 464 00:22:51,600 --> 00:22:55,560 that they've studied for six years in some medical field 465 00:22:55,560 --> 00:22:56,640 or some research field, 466 00:22:56,820 --> 00:22:58,440 and at the end of it, they did well, 467 00:22:58,520 --> 00:22:59,400 they feel intelligent, 468 00:22:59,640 --> 00:23:01,140 but as they start to reflect back, 469 00:23:01,340 --> 00:23:04,020 everything from 16 or before is gone. 470 00:23:04,400 --> 00:23:05,740 And so, yeah. 471 00:23:05,840 --> 00:23:07,220 And there's some research that shows 472 00:23:07,220 --> 00:23:09,860 there may be an NGF-based mechanism. 473 00:23:09,980 --> 00:23:11,280 That may be why you can't 474 00:23:11,300 --> 00:23:13,220 remember your really early childhood, 475 00:23:13,440 --> 00:23:15,960 not because it's locked behind some psychological block, 476 00:23:16,200 --> 00:23:18,400 but because you've used that space up 477 00:23:18,400 --> 00:23:21,160 and reconfigured it to store later memories. 478 00:23:21,500 --> 00:23:24,160 So, with NUPEPT in particular, 479 00:23:24,320 --> 00:23:25,320 I just wanted to mention this one, 480 00:23:26,060 --> 00:23:28,780 NUPEPT, the reason I never experimented with NUPEPT 481 00:23:28,780 --> 00:23:31,120 past sort of an initial getting to know you phase, 482 00:23:31,340 --> 00:23:34,040 was after about six weeks of supplementation, 483 00:23:34,100 --> 00:23:36,180 I was looking in the mirror at one point 484 00:23:36,180 --> 00:23:38,560 and didn't recognize my reflection. 485 00:23:38,880 --> 00:23:40,140 I knew who I was, 486 00:23:40,280 --> 00:23:41,280 but when I tried to stop 487 00:23:41,300 --> 00:23:43,260 and think like, what do I look like? 488 00:23:43,420 --> 00:23:46,620 My residual self-image had been overwritten, 489 00:23:46,720 --> 00:23:48,640 or at least interfered with in some way. 490 00:23:48,780 --> 00:23:50,060 And so, again, that was enough to go like, 491 00:23:50,100 --> 00:23:52,340 no, I'm not, it's not worth it. 492 00:23:53,040 --> 00:23:54,480 So, NUPEPT, again, is really cheap. 493 00:23:54,560 --> 00:23:56,580 A year's supply is gonna run you $5. 494 00:23:57,060 --> 00:24:00,040 So, this experimentation is very accessible 495 00:24:00,040 --> 00:24:02,080 even to those with very little resources. 496 00:24:02,880 --> 00:24:03,780 So, thank you guys.