WEBVTT 00:00.000 --> 00:13.380 Now, I do have some written things up here but these two speakers are two of the best that we've had and I feel if I would give them an introduction it would be an insult. 00:13.380 --> 00:24.060 So here today, uh, speaking on how your doctor might be trying to kill you and how personal genomics can save your life, ladies and gentlemen, Jen and Darren. 00:26.060 --> 00:27.180 Thanks a lot. 00:30.060 --> 00:35.500 Alright, so indeed, how your doctor might be trying to kill you and how personal genomics can save your life. 00:35.500 --> 00:48.320 So, just real quick, the idea here is that personal medicine, the drive to own your health a little bit more and working with your doctor is a big deal. 00:48.760 --> 00:53.920 You know, it's a half hour talk, we just want to provide a couple of anecdotes to kind of drive that point home a little bit. 00:53.920 --> 01:03.840 And along the way also, maybe give you some ideas and some information related to genomics and how you can help yourself down that path. 01:04.120 --> 01:13.260 So, the obligatory disclaimer, we're not doctors and we are not working for our company right now, so. 01:13.820 --> 01:17.860 And I'm going to hand it over to Mike, or to Mike, I'm going to hand the mic over to Jen. 01:18.680 --> 01:19.980 Thank you. 01:20.040 --> 01:26.480 So, before we really get into some of the details, there are some basics that we should go over, just some terminology. 01:27.280 --> 01:32.820 Genome sequencing, when you see commercials like 23andMe, they're sequencing parts of your DNA. 01:33.480 --> 01:36.140 That's how you get information about your genome. 01:37.140 --> 01:42.420 Something that they will give you is called SNPs, single nucleotide polymorphisms. 01:42.420 --> 01:48.040 The way to remember this is just, is where you vary from what is considered normal. 01:48.120 --> 01:54.860 So, your SNP might be that you have a variant that is defective or just not normal. 01:55.320 --> 01:58.540 And then you have personalized medicine, or precision medicine. 01:58.540 --> 02:04.600 This is tailoring your medical prescription based on your DNA, based on your genetic code. 02:04.780 --> 02:06.640 And then there's gene expression. 02:06.760 --> 02:13.840 Just because you have some malfunction or some DNA variance does not mean it will actually be expressed. 02:13.860 --> 02:16.620 There's turning on of genes and turning off of genes. 02:16.620 --> 02:20.160 Just because you have something doesn't mean it will actually express or show. 02:20.700 --> 02:22.100 And then we have epigenetics. 02:22.100 --> 02:27.880 Your environment, things that you consume, alcohol, tobacco, can also affect you at a DNA level. 02:27.900 --> 02:40.200 It's very important to know because if you're going to explore your own genome, you'll want to be very familiar that just because it says you have something that might be defective does not mean you actually have it. 02:42.660 --> 02:50.360 So, I want to share with you an experience that I've had with my personal genome and how it's affected my life. 02:51.320 --> 02:55.780 About ten years ago, one day, I developed a very severe headache. 02:56.160 --> 03:02.660 So severe, in fact, that when I went to bed, I was hoping and praying, please let me wake up in the morning. 03:03.080 --> 03:04.120 Now, here's a tip. 03:04.120 --> 03:09.240 If you're going to bed praying that you wake up in the morning, you should probably be going to the hospital. 03:09.460 --> 03:11.040 But I just want to shake it off. 03:11.040 --> 03:12.320 I got this. 03:12.660 --> 03:15.620 And I tried to go to sleep until about five in the morning. 03:15.620 --> 03:19.640 It was very clear I needed medical attention immediately. 03:19.700 --> 03:21.800 So, rushed to the emergency room. 03:21.800 --> 03:22.740 I got there. 03:22.740 --> 03:27.220 I'm in such excruciating pain, I can't even answer my doctor's questions. 03:27.220 --> 03:29.720 I can't even communicate with my doctor. 03:29.800 --> 03:39.660 So, they give me a really, really good sedative, gave me a good dose of Dilaudid, put me in an MRI, and took some pretty pictures. 03:40.000 --> 03:41.320 Here are two of them. 03:41.420 --> 03:42.800 This is my brain. 03:43.340 --> 03:52.400 And as I come out of the MRI, feeling really good on Dilaudid, my doctor tells me, you have a two-inch blood clot in your brain. 03:52.400 --> 03:56.160 If you did not get here by now, you would be dead. 03:56.720 --> 04:00.420 So, I wonder, how did this happen? 04:00.420 --> 04:07.680 As did my doctor, being of a somewhat young age, developing a blood clot that large in your brain is not exactly normal. 04:07.920 --> 04:27.900 So, he does some basic genetic testing on me, takes about 15 vials of blood, and comes back and tells me that, you know those commercials where they tell you about medicine and it's about two seconds worth telling you what the medicine does and the rest of the time it's telling you how it could kill you, 04:27.900 --> 04:34.060 how you shouldn't take it with certain defects or certain, with alcohol or breathing oxygen. 04:34.060 --> 04:35.880 There's a reason for that. 04:36.000 --> 04:40.620 This is a typical medical disclaimer regarding birth control pills. 04:40.880 --> 04:51.540 And there's a lot here, but what's hidden in there, you should not take birth controls if you have a hereditary or acquired predisposition for blood clots. 04:51.560 --> 04:53.400 Well, how do you even know if you do? 04:54.100 --> 04:57.160 If you haven't had your genetic testing done, you have no idea. 04:57.160 --> 05:04.960 So, you might be taking medicine or pills or even vitamins that could actually be hurting you when you're not knowing it. 05:05.020 --> 05:06.900 So, this is exactly what I had. 05:06.980 --> 05:12.400 I had been taking birth control pills and I had a hereditary or acquired predisposition. 05:12.400 --> 05:19.980 My doctor comes to me and says, congratulations, your homozygous C677T for MTHFR genetic mutation. 05:20.080 --> 05:20.780 What? 05:21.000 --> 05:22.460 What is that? 05:22.460 --> 05:29.760 So, he tries to explain to me that it's something that a lot of people have and that there is this pathway here. 05:29.760 --> 05:32.000 I'm not going to go into the details. 05:32.000 --> 05:36.100 This, everyone has, and this is responsible for many things. 05:36.100 --> 05:51.100 When this works properly, it is responsible for making DNA, maintaining your DNA, repairing your DNA, regulating gene expression, that's the turning on and off of genes, regulating hormone function, regulating histamine levels. 05:51.100 --> 05:55.800 It's responsible for a lot of really important things in your life. 05:55.800 --> 05:59.080 So, when this isn't working, what could go wrong? 05:59.380 --> 06:01.280 Well, apparently a lot. 06:02.080 --> 06:05.660 And this isn't even everything. 06:05.960 --> 06:19.140 If you have these mutations and if you do not have the proper balance in that pathway, you could be under-methylating, not producing enough, or over, and that's too much. 06:19.140 --> 06:20.420 So, there's no balance there. 06:20.420 --> 06:27.320 You could have any one of these things, including blood clots, which is, lucky for me, what I had. 06:27.600 --> 06:34.700 So, I had some questions, and this is actually what my pathway looks like. 06:34.700 --> 06:37.840 And in medical terms, this is called severely jacked up. 06:37.840 --> 06:39.480 This is not good. 06:40.100 --> 06:43.300 So, I do what I refer to as under-methylating. 06:43.300 --> 06:45.640 I don't do that properly. 06:46.720 --> 06:50.080 And so, my doctor says, here's what you've got to do. 06:50.080 --> 06:51.240 Can't smoke. 06:51.520 --> 06:53.320 Don't take birth control pills. 06:53.580 --> 06:54.780 And, you know what? 06:54.780 --> 06:55.740 You're of child-bearing age. 06:55.740 --> 06:57.080 Take some folic acid. 06:57.080 --> 07:01.760 Take some multivitamins, just as general advice the doctors give, and sends me on my way. 07:02.640 --> 07:08.860 Fortunately, I don't follow directions very well, and I hate taking pills, so I didn't listen to him. 07:09.120 --> 07:10.560 I did not take folic acid. 07:10.560 --> 07:12.380 I did not take multivitamins. 07:12.380 --> 07:17.640 And it's a good thing, because actually, he did not mean to kill me with this advice. 07:17.640 --> 07:18.680 I'm sure he didn't. 07:18.680 --> 07:19.820 I like to think he didn't. 07:19.820 --> 07:21.760 I think I paid my bills on time. 07:22.360 --> 07:27.660 But, what he was prescribing for me could potentially have killed me or put me back in the hospital. 07:27.860 --> 07:33.200 Because folic acid and multivitamins, in some forms, is actually poison to me. 07:33.700 --> 07:35.120 So, good thing I didn't listen. 07:35.480 --> 07:37.540 I had to have some dental work done. 07:37.540 --> 07:39.200 I went to the dentist, and Mr. 07:39.200 --> 07:42.700 Dentist says, hey, would you like some nitrous oxide for this? 07:42.740 --> 07:46.220 It will make you feel mellow, make it a little easier for the procedure. 07:46.400 --> 07:47.300 Sure. 07:47.480 --> 07:48.460 Give me some nitrous oxide. 07:48.460 --> 07:49.260 I want to feel mellow. 07:49.260 --> 07:52.600 I want to enjoy this procedure instead of being in pain. 07:52.640 --> 07:54.560 So, everything goes fine. 07:54.560 --> 07:55.640 Nothing happened. 07:55.640 --> 08:01.260 It was great, which is very fortunate, because there are many, many, many documented cases. 08:01.260 --> 08:06.840 People who did not know that they had some genetic defects that are contraindicative with nitrous oxide. 08:06.840 --> 08:10.720 And they did not leave the dentist office alive. 08:11.180 --> 08:13.480 So, fortunately, for me, I was fine. 08:13.760 --> 08:18.860 I had a friend who happens to have the same genetic mutation as I do. 08:18.860 --> 08:20.820 And I told her, I just went to the dentist. 08:21.240 --> 08:26.600 Fortunately for me, she was a lot more well-educated in our genetic mutation than I was at the time. 08:26.600 --> 08:30.060 And she told me, you need to research this. 08:30.060 --> 08:35.680 You need to really find out, because your doctor is giving you information that really is not helpful for you. 08:35.780 --> 08:38.200 And there's more that you need to learn. 08:38.740 --> 08:42.100 So, it's clear I needed to learn more about my DNA. 08:42.380 --> 08:43.900 What is that process like? 08:45.020 --> 08:46.720 So, this is where I jump in. 08:46.720 --> 08:49.680 So, I want to do the same thing. 08:49.680 --> 08:53.040 So, I'm like probably a zillion other people, probably a lot of other folks in this room. 08:53.040 --> 09:02.360 I wanted to check out one of these commercial, you know, companies and get my stuff looked at, see what I could find out. 09:02.360 --> 09:06.320 And, you know, I'm sure a lot of people have this kind of reasoning behind it as well. 09:06.320 --> 09:11.360 You can imagine folks that maybe are adopted or maybe think they're adopted or whatever. 09:11.360 --> 09:15.480 I have, my father's been out of the picture since I was like four. 09:15.480 --> 09:17.400 I know nothing about his family. 09:17.440 --> 09:29.260 So, I thought, you know, aside from all of the other sort of interesting things, maybe there's gaps there, there's interesting things there that might be medical-related kind of things that I might be able to discover and help fill that gap a little bit. 09:29.260 --> 09:30.980 So, I went and had it done. 09:31.940 --> 09:35.740 Oh, and let me mention too, and maybe some of you guys are the same way. 09:35.740 --> 09:42.040 Also, the ancestry side, I was kind of like, you know, it'd be very cool if I had some sort of hidden lineage, right? 09:42.040 --> 09:49.920 And, you know, I'm part like Cherokee or, you know, I have like East African descent or something crazy like that, right? 09:49.920 --> 09:53.100 So, I get all this done and I had that there as well. 09:53.460 --> 10:03.380 And so, one of the things, just so you know, and that's why I have the picture that came out of this, is that I'm really, really Caucasian. 10:04.740 --> 10:09.060 And it's... I was disappointingly Caucasian. 10:10.300 --> 10:12.020 I'm like translucent. 10:12.020 --> 10:19.500 I'm not entirely sure that you can get any more, you know, white European than that and I was truly disappointed. 10:19.500 --> 10:28.380 But the point I'm trying to make here is that you get all the information from there and it's a pretty good set of information. 10:28.520 --> 10:38.060 And oftentimes, you'll find a little tweak here, a little thing there that you're like, oh, you might have this thing or you might be carrying this thing or, you know, there's all the ancestry bits. 10:38.060 --> 10:40.220 But it is very consumer based, right? 10:40.220 --> 10:42.340 It's very high level. 10:42.940 --> 10:47.120 You can, in some cases, dig into things and I very much recommend that. 10:47.120 --> 10:50.100 But also, there's other places you can take that data. 10:50.260 --> 10:51.920 And that's the purpose here. 10:51.920 --> 10:57.140 If you look at the stuff above the line here, that's stuff from 23andMe. 10:57.360 --> 10:59.980 So, that's just a snippet of some of my information. 10:59.980 --> 11:01.000 Super high level, right? 11:01.000 --> 11:03.080 It's a, hey, variant not detected. 11:03.180 --> 11:04.600 You know, these items. 11:04.740 --> 11:06.280 Real easy to read, real easy to consume. 11:06.280 --> 11:07.600 I get that understanding. 11:07.660 --> 11:08.320 Nice. 11:09.360 --> 11:14.520 Side note, you can download all of the SNP data, the raw SNP data. 11:14.520 --> 11:19.600 And that's where, then you can take that raw SNP data and you can go and plug it into other places. 11:20.080 --> 11:26.360 This one down here is Code... Code... Code... Who knows? 11:26.420 --> 11:26.860 Codegent. 11:26.860 --> 11:29.280 So, this one down here is just an example of some of the stuff from Codegent. 11:29.280 --> 11:30.240 And it gives you an idea, right? 11:30.240 --> 11:35.840 So, the, uh, the point here is, is, uh, you see that increased risk of type 2 diabetes? 11:36.220 --> 11:39.440 That was nowhere in my, in my 23andMe one. 11:39.460 --> 11:42.780 So, different system, different analysis. 11:42.780 --> 11:44.780 You get some, some, fill in some gaps. 11:44.780 --> 11:45.580 It's kind of cool. 11:45.580 --> 11:47.960 Another thing you might notice with the search, look at the search bar. 11:48.360 --> 11:53.980 That's searching your SNPs for references to all kinds of things. 11:54.000 --> 12:00.240 Uh, chemicals, drugs, diseases, uh, and obviously the, the genes themselves. 12:00.240 --> 12:05.880 So, if you have a specific interest, hey, am, am I, is there issues with me drinking alcohol? 12:05.880 --> 12:08.060 Am I, am I predisposed to being an alcoholic? 12:08.180 --> 12:11.300 That might be a, a, an easy way to dig into it. 12:11.300 --> 12:17.480 Um, again, the point here is there are some simple places, simple ways you can get to, um, more data. 12:17.480 --> 12:18.800 You can fill your data up. 12:18.800 --> 12:21.220 You, I mean, you can, you can fill those gaps a little bit. 12:21.220 --> 12:24.160 And the nice thing about this one as well, you can dig in a little bit more deeply. 12:24.160 --> 12:25.120 You can drill in. 12:25.140 --> 12:26.820 Um, and there's, there's many, many more. 12:26.820 --> 12:27.780 Some of them are free. 12:27.780 --> 12:29.100 Some of them are not free. 12:29.520 --> 12:34.100 Um, so what, next, what's the moral of the story? 12:34.180 --> 12:36.400 Moral of the story is information is power, right? 12:36.400 --> 12:38.560 We all want, we want more information. 12:38.740 --> 12:40.920 Uh, the more information you have, the stronger you can be. 12:42.860 --> 12:53.660 But... Not just that, if you know your genetic code, if you know your predispositions, if I had known mine, perhaps I never would have taken those birth control pills and I wouldn't have ended up in the hospital. 12:53.760 --> 12:55.800 So if you know ahead of time, you're armed. 12:55.980 --> 12:57.480 Information is power. 12:57.740 --> 13:01.500 It's also not all, not all information is power. 13:01.740 --> 13:07.460 Um, me being the hacker mentality that I have, um, well my doctor doesn't really know what I need. 13:07.460 --> 13:09.640 I know my genetic code now, mostly. 13:09.640 --> 13:11.400 I'm gonna, I'm gonna fix this. 13:11.400 --> 13:15.700 So I go on the internet and I look at other people who've contributed information. 13:15.700 --> 13:21.660 This is what you need to do, this is how you get from under-methylating, like I am, to a normal state. 13:21.660 --> 13:25.660 So I can repair my DNA, I can do all of those good things. 13:26.040 --> 13:28.660 Well, it didn't work out so well for me there either. 13:28.660 --> 13:35.920 Um, I took all the right form of vitamins and, um, one day I'm taking these vitamins and I hit the floor. 13:35.920 --> 13:37.020 I pass out. 13:37.040 --> 13:42.800 Um, me not learning very quickly, I do it again the next day, I pass out. 13:42.900 --> 13:45.240 Clearly I need to stop taking these vitamins. 13:45.240 --> 13:46.560 I do and everything's fine. 13:46.560 --> 13:49.120 But what happened is I, I, I changed the balance. 13:49.120 --> 13:53.140 I under-methylated and then I over-methylated and it was just as bad. 13:53.140 --> 13:56.020 And in fact it was, it was very dangerous. 13:56.440 --> 14:00.320 So don't read everything, don't believe everything you read on the internet. 14:00.320 --> 14:03.780 Not because it's wrong, because it might be wrong for you. 14:04.560 --> 14:08.120 You need... Wait, what did I say? 14:08.120 --> 14:10.880 Did you just say don't believe everything you read on the internet? 14:15.660 --> 14:21.280 And so what's important to take here is, yeah, you need to be a steward of your own, your own health. 14:21.280 --> 14:22.440 You need to be educated. 14:22.440 --> 14:23.260 You need to be knowledgeable. 14:23.380 --> 14:26.740 But you also need to enlist the help of a really good doctor. 14:26.760 --> 14:30.180 One that is interested in helping you based on you. 14:30.180 --> 14:31.920 Not just what is normal. 14:31.980 --> 14:33.980 Um, they're really good at treating sick. 14:34.220 --> 14:37.320 They're not so good at treating you specifically. 14:37.640 --> 14:38.980 But you need to help them. 14:38.980 --> 14:43.960 And if you do that, you can, um, you can come to a much better place. 14:45.540 --> 14:51.800 I'll also make the point that the title of the slide is how, or the other of the talk is how your doctors are trying to kill you. 14:52.240 --> 14:59.000 Certainly hyperbole, the idea there is that you need to, uh, be the steward of your own, your own health. 14:59.120 --> 15:03.160 Uh, doctors are there to, to do that as well. 15:03.160 --> 15:07.000 Some doctors aren't, aren't hip to folks trying to help them out. 15:07.000 --> 15:11.600 And you know, maybe that, and if that's what you're looking for, then you need to find another doctor. 15:14.140 --> 15:16.880 A couple of, we want to touch on a couple of other things. 15:16.880 --> 15:17.720 Um, risk. 15:17.720 --> 15:19.020 Man, there are tons of risk, right? 15:19.020 --> 15:25.720 And, and I think that, that this, this set of things here could be a three hour panel discussion easily, right? 15:25.780 --> 15:29.480 Um, all of the ethical, uh, concerns, all of the security risk. 15:29.480 --> 15:30.220 Here's the thing. 15:30.220 --> 15:34.980 I, I, this company generated SNP data for me. 15:35.400 --> 15:36.360 They have it. 15:36.360 --> 15:37.400 I have it, which is nice. 15:37.400 --> 15:39.640 At least I have control of what I have. 15:39.980 --> 15:41.060 What control do they have? 15:41.060 --> 15:42.860 What are they going to do with it over time? 15:42.860 --> 15:44.260 Who do they share it with? 15:44.320 --> 15:46.500 What happens when they get bought by another company? 15:46.500 --> 15:58.500 What happens when the country that they're, that they're incorporated in gets, uh, has a military coup and is now a fascist company or, you know, our country, you know, all of these questions are, are significant questions and you have to ask yourself what you're comfortable with. 15:58.500 --> 16:02.180 You also have to ask yourself, you know, what's the risk versus reward? 16:02.180 --> 16:08.840 Is this something, um, these are difficult things, I think. 16:09.080 --> 16:15.380 Um, I don't, and we're not going to answer those things up here, but just to say that we recognize that they're there. 16:16.800 --> 16:22.400 Oh, this is some of those, this is another risk of some sort, right? 16:22.720 --> 16:24.800 Uh, oh, that's not my brother. 16:25.480 --> 16:31.480 Or, oh, this guy, uh, you know, and what, what, how many, what's, where did these come from? 16:31.960 --> 16:34.120 Sorry, this is from the 23andMe forums. 16:34.120 --> 16:36.060 This is just from one month alone. 16:36.060 --> 16:38.760 People saying, wow, I have a half sister I didn't know about. 16:38.820 --> 16:39.740 That's not my dad. 16:39.740 --> 16:40.900 And I thought it was. 16:40.900 --> 16:41.660 I think you have... 16:41.660 --> 16:42.220 Yeah, yeah. 16:42.220 --> 16:46.320 So I have a friend who's a woman, she's, uh, in her seventies. 16:46.640 --> 16:53.380 Um, and she went and had, uh, this done with ancestry and turns out her father was not her father. 16:53.840 --> 17:00.340 And I thought to myself, that's a fantastic, that's an incredible thing to learn after, at, at 70. 17:00.400 --> 17:05.880 I mean, that's 70 years of this is who I am and now that's not who I was. 17:05.880 --> 17:06.680 That's crazy. 17:06.680 --> 17:13.440 And, you know, both of her parents have passed away and her, her father, who she never knew was her father, has also passed away. 17:13.440 --> 17:19.620 So there's no, like, there's not much to do there, but man, what a, what a fantastic and crazy thing to have happened. 17:20.180 --> 17:23.860 So, uh, we'll just leave you with some resources. 17:23.860 --> 17:29.500 And there are several, um, places that you can take that data and do more with that data. 17:29.680 --> 17:31.460 Um, Live Wellow is an interesting one. 17:31.460 --> 17:32.800 That's the one with, oh, NutriHacker. 17:32.800 --> 17:37.140 No, NutriHacker is the one that, uh, wait, which one is Live Wellow? 17:37.140 --> 17:55.260 The one that like will guide you through NutriHacker will guide you through, uh, based on your, uh, genetic data will guide you through like life decisions and, and, uh, uh, yeah, food, food choices and drug choices and those kinds of things and give you some guidance based purely on your, 17:55.260 --> 18:05.860 on your DNA, which, you know, keep in mind that's, that's basing a lot on maybe a little, so, you know, use some, use some common sense. 18:06.080 --> 18:09.020 Oh, and then there's even some more deep stuff here. 18:10.140 --> 18:11.400 It's a little deeper. 18:12.400 --> 18:20.220 Yeah, so the, the previous slide would show you how to, to get some pretty reports and really look at things from a higher level, easy to read. 18:20.580 --> 18:35.100 Um, this is if you want to dig deeper, you can do so much with this set of resources and this is not comprehensive by any means, but this can allow you to really dig into the exact research that, um, that is involved with each of the SNPs or in each of your variations. 18:35.120 --> 18:40.940 You can spend months just looking at probably one variation in your genome. 18:41.020 --> 18:43.160 Um, but this is a really good place to start. 18:43.220 --> 18:49.460 Again, not comprehensive, but, um, I encourage you guys to go out and, and learn about yourself. 18:50.340 --> 18:51.040 Yeah. 18:51.040 --> 18:57.630 So I don't know that we're the type that we can answer any questions, but there isn't. 18:57.630 --> 18:58.630 Thank you. 18:59.090 --> 19:00.210 Yes. 19:08.310 --> 19:11.550 I'm just curious what the process is for these companies. 19:11.590 --> 19:20.230 Um, what, what sort of, uh, generic material do you send them for testing and is it possible to do it anonymously? 19:21.130 --> 19:23.470 Oh, anonymously is a good question. 19:23.610 --> 19:24.890 Oh, she, she must know something. 19:24.890 --> 19:25.190 Yeah. 19:25.190 --> 19:31.250 So most of them are, are, are basically a spit culture of some sort and they send you all this stuff. 19:31.250 --> 19:35.450 They make it super easy and you got to generate some level and you got to spin into the same. 19:35.450 --> 19:40.570 I think it, you know, it feels like a court of spit, but it's really, uh, not that much. 19:41.350 --> 19:42.710 What were we going to say about the anonymous? 19:42.710 --> 19:43.270 Oh yeah. 19:44.330 --> 19:53.130 So when I went into this being a, you know, cyber security professional, I have concerns about my privacy tied to my, my genetic DNA. 19:53.190 --> 19:58.750 Uh, I registered as anonymous, but one of the risks is how anonymous is anonymous. 19:58.750 --> 20:05.390 And not only that, but to get the rich information, how much do you have to disclose that you're, you're avoiding that anonymity? 20:05.390 --> 20:08.730 But there are ways to do it anonymously. 20:08.790 --> 20:11.250 Um, you could just build your own lab. 20:11.250 --> 20:14.130 I'm sure we're not that far away from that. 20:14.130 --> 20:15.110 I'm hoping. 20:15.110 --> 20:18.710 Uh, it is quite expensive now, but everything gets cheaper and cheaper. 20:18.710 --> 20:20.470 So, um, yeah. 20:22.190 --> 20:22.970 Yes. 20:58.180 --> 20:58.820 Yeah. 20:58.820 --> 20:59.180 Yeah. 20:59.180 --> 21:00.320 That does sound like a talk. 21:01.140 --> 21:03.360 If you do that talk, I want to be there for that. 21:04.660 --> 21:05.360 Yeah. 21:05.420 --> 21:21.600 Um, I want to know how, uh, how prevalent are SNPs, single nucleotide polymorphisms, and also, uh, how much, uh, almost like what's the breadth, how much research is done on each variation, each occurrence, and what's the odds of what you have actually being something significant? 21:21.600 --> 21:28.060 To answer that, I want to go with how companies like 23andMe, um, sequence your, your genetic code. 21:28.060 --> 21:30.880 They don't take, they don't see everything about you. 21:30.880 --> 21:37.260 There are certain common variations that they test for, and they, they compare it to your DNA. 21:37.460 --> 21:39.920 And what, that's where the SNPs come in. 21:40.860 --> 21:43.480 So, they're common. 21:43.700 --> 21:45.120 Uh, they're very common. 21:45.120 --> 21:50.660 Whether they're expressed or turned on or off is, is another, uh, debate, but they're very common. 21:50.660 --> 21:55.940 Um, in fact, the, the, what I said, I have the MTHFR homozygous C677D. 21:55.940 --> 21:58.260 Uh, about a third of you probably are the same. 21:58.260 --> 21:59.760 It's, it's pretty common. 22:00.080 --> 22:07.460 Yeah, and I'll, and I'll say some of them are, you know, saying you have a mutation or a variant , sometimes, you know, that can sound like something. 22:08.020 --> 22:13.680 Not only is there the issue of expression and epigenetics, but there's also just the fact that sometimes it's just for something goofy. 22:13.680 --> 22:17.100 Like, I can smell, uh, uh, asparagus in people's pee. 22:17.260 --> 22:22.860 So, uh, you know, it's, it's nothing, nothing to be, like, to fret over necessarily. 22:23.520 --> 22:28.100 Veritas Genetics will do your entire, uh, genome now for a thousand U.S. 22:28.120 --> 22:29.500 It's coming down. 22:29.500 --> 22:31.300 Are you thinking of doing that? 22:31.300 --> 22:31.720 Ooh. 22:31.720 --> 22:32.300 I am. 22:32.300 --> 22:32.860 Yeah? 22:32.860 --> 22:33.740 Definitely. 22:36.490 --> 22:38.470 Plus, plus they're doing a lot. 22:38.470 --> 22:40.710 That's another interesting thing about these companies too. 22:40.710 --> 22:42.770 Now they have this amazing data set, right? 22:42.790 --> 22:48.710 Um, and they're, they're now doing correlations where they would have never known there was a correlation before. 22:48.710 --> 22:50.210 And it's, and it's, and it's good. 22:50.210 --> 22:53.990 And some of it's goofy, but the, but the, the proof of concept is there and they're fine. 22:53.990 --> 23:05.670 And they're, they're starting to get to the point where they can say based on previous data that we've seen, we know that you have a 80% chance of, you know, something goofy, cleft chin or something. 23:05.910 --> 23:07.410 Last question. 23:07.530 --> 23:09.490 Um, so great talk. 23:09.490 --> 23:11.830 Thanks very much for sharing your personal stories. 23:11.830 --> 23:18.670 And one of the challenges of genetics is even if you do all of that, you'll potentially not anonymous because we can find you. 23:19.190 --> 23:23.750 It's maybe five to 10 other factors and we'll identify you. 23:23.870 --> 23:35.050 So the law currently says from a medical standpoint in this country, you cannot be prevented from accessing preexisting condition. 23:35.050 --> 23:47.290 The challenge is that that's not true from insurance and you can be declined insurance as a result of it, which makes what you've done essentially a risk. 23:47.290 --> 23:48.090 Absolutely. 23:48.090 --> 23:50.130 Um, I've been fully sequenced. 23:50.130 --> 23:52.190 I've had a full genome sequence. 23:52.190 --> 23:56.170 I've had 23 and me, um, as part of an exploration. 23:56.170 --> 24:02.830 And one of the challenges I find with that is that there's a real disconnect with the data and the reality of exploring it. 24:02.830 --> 24:08.410 Certainly when it got faxed to my general practitioner as a printed report, which was just preposterous to me. 24:09.050 --> 24:27.230 Um, I, I'm just curious to know what you think about the impact that that's had on you or has it, has that changed anything from your world in terms of... So I haven't, I haven't experienced any explicit impact, uh, related to like, uh, insurance coverage and any of those kinds of things. 24:27.230 --> 24:28.610 But that's an interesting question, right? 24:28.610 --> 24:30.570 That's one of the risks that we may have. 24:30.570 --> 24:32.350 It's one of the things I don't know that we've solved. 24:32.350 --> 24:33.730 I think some people think it's solved. 24:33.730 --> 24:35.310 I don't think it's really solved for sure. 24:35.330 --> 24:47.370 I, I'm one of the guys, um, that is more willing to be, I'm more willing to give up more of my privacy to get more stuff out of, out of life. 24:47.570 --> 24:53.650 Um, I know that's contrary to this, this whole crowd, but I'm, I'm, I'm kind of like, I'm kind of like Joe U.S. 24:53.650 --> 24:58.450 I'm, I'm, I'm, I'm, I'm a guy that's gonna tell me some stuff and, and let's see what happens. 24:59.290 --> 25:01.050 Security through obscurity, right? 25:01.070 --> 25:06.110 Um, and I think a lot of people are that way, but, and I think that at the end of the day, there's some serious risk there. 25:07.610 --> 25:09.590 I, I don't know if that answered your question. 25:09.610 --> 25:11.050 I haven't run into anything. 25:11.050 --> 25:12.650 I think that's a fair comment. 25:12.650 --> 25:21.470 And ultimately, I think we all give up our privacy at the point that we have a catastrophic illness or a condition because at that point, who cares? 25:21.470 --> 25:28.430 I need all So, I think it's not an unreasonable, and I don't want anybody to stab me in this circumstance. 25:28.430 --> 25:33.270 But at some point, you've got to give up something to get all of that. 25:33.790 --> 25:35.610 And, you know, it's finding the balance. 25:35.750 --> 25:36.550 Agreed. 25:36.630 --> 25:37.250 Nice. 25:37.330 --> 25:38.250 Okay, I think that's it, folks. 25:38.250 --> 25:39.450 Thank you guys very much.