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Well, I do have some written things up here, but these two speakers are two of the best

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that we've had. And I feel if I would give them an introduction, it would be an insult. So

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here today, speaking on how your doctor might be trying to kill you and how personal

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genomics can save your life, ladies and gentlemen, Jen and Darren. Thanks a lot.

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Alright, so indeed, how your doctor might be trying to kill you and how personal genomics can

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save your life. So, just real quick, the idea here is that personal medicine, the drive to own

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your health a little bit more and working with your doctor is a big deal. You know, it's a

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half-hour talk. We just want to provide a couple of anecdotes to kind of drive that point home a

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little bit. And along the way, also, maybe give you some ideas and some information related to

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genomics and how personal genomics can save your life. So, thank you.

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Thank you. So, I'm going to hand it over to Mike. I'm going to hand the mic over to Jen.

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Thank you. So, before we really get into some of the details, there are some basics that we

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should go over. Just some terminology. Genome sequencing. When you see commercials like 23 and

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24, you know, I'm going to say that they're sequencing parts of your DNA. That's how you get

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information about your genome. Something that they will give you is called SNPs. Single

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nucleotide polymorphisms. The way to remember this is just where you vary from what is

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considered normal. So, your SNP might be that you have a variant that is defective or just not

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normal. And then you have personalized medicine or precision medicine. This is tailoring your

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medical prescription based on your DNA, based on your genetic code. And then there's gene

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expression. Just because you have some malfunction or some DNA variance does not mean it will

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actually be expressed. There's turning on of genes and turning off of genes. Just because you

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have something doesn't mean it will actually express or show. And then we have epigenetics.

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Your environment, things that you consume, alcohol, tobacco, can also affect you at a DNA level.

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It's very important to know because if you're going to be a geneticist, you're going to have to

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explore your own genome. You'll want to be very familiar that just because it says you have

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something that might be defective does not mean you actually have it. So, I want to share with

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you an experience that I've had with my personal genome and how it's affected my life. About ten

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years ago, one day, I developed a very severe headache. So severe, in fact, that when I went to

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bed, I was hoping that I was going to die. I was hoping that I was going to die. I was hoping that

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if I wasn't reagting to the message, I might damage my lymphed 울ty οι групп,

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thoseшаяş trap Disease Processing Again. Now, I heard some Umphs and jumping in praying.

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Please let me wake up in the morning. Now, here's a tip. If you're going to bed, praying that you

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wake up in the morning, you should probably be going to the hospital. But I just want to

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shake it off, I got this, and I tried to go to sleep until about five in the morning. It was very

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clear I needed medical attention immediately. So, rushed to the emergency room. I get there. I'm in

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in such excruciating pain, I can't even answer my doctor's questions. I can't even communicate

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with my doctor. So they give me a really, really good sedative, give me a good dose of Dilaudid,

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put me in an MRI, and took some pretty pictures. Here are two of them. And this is my brain.

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And as I come out of the MRI, feeling really good on Dilaudid, my doctor tells me,

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you have a two-inch blood clot in your brain. If you did not get here by now, you would be dead.

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So I wonder, how did this happen? As did my doctor. Being of a somewhat young age,

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developing a blood clot that large in your brain is not exactly normal.

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So he does some basic genetic testing on me, takes about 15 vials of blood, and comes back

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and tells me that,

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you know those commercials where they tell you about medicine, and it's about two seconds worth

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telling you what the medicine does, and the rest of the time is telling you how it could kill you,

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how you shouldn't take it with certain defects or certain, with alcohol or breathing oxygen?

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There's a reason for that. This is a typical medical disclaimer regarding birth control pills.

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And there's a lot here, but what's hidden in there, you should not take birth controls if you

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have a hereditary,

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or acquired predisposition for blood clots. Well, how do you even know if you do?

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If you haven't had your genetic testing done, you have no idea. So you might be taking medicine, or pills, or even

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vitamins that could actually be hurting you when you're not knowing it. So this is exactly what I had.

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I had been taking birth control pills, and I had a hereditary, or acquired predisposition. My doctor comes to me and says,

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congratulations, your homozygous C677T for MTHL-1, and you have a predisposition.

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And I'm like, what? What? What is that?

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So he tries to explain to me that it's something that a lot of people have, and that there is this pathway here.

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I'm not going to go into the details. This, everyone has, and this is responsible for many things.

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When this works properly, it is responsible for making DNA, maintaining your DNA, repairing your DNA,

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regulating gene expression, that's the turning on and off of genes.

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Regulating hormone function, regulating histamine levels, it's responsible for a lot of really important things in your life.

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So when this isn't working, what could go wrong?

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Well, apparently a lot.

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And this isn't even everything.

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If you have these mutations, and if you do not have the proper balance in that pathway,

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you could be under-methylating, not producing enough, or over.

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And that's too much.

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So there's no balance there.

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You could have any one of these things, including blood clots, which is lucky for me what I had.

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So I had some questions.

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And this is actually what my pathway looks like.

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And in medical terms, this is called severely jacked up.

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This is not good.

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So I do what I refer to as under-methylating.

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I don't do that properly.

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And...

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So my doctor says, here's what you got to do.

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Can't smoke.

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Don't take birth control pills.

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And you know what?

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You're of childbearing age.

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Take some folic acid.

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Take some multivitamins, just as general advice the doctors give, and sends me on my way.

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Fortunately, I don't follow directions very well, and I hate taking pills.

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So I didn't listen to him.

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I did not take folic acid.

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I did not take multivitamins.

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And it's a good thing, because actually, he did not mean to kill me with this advice.

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I'm sure he didn't.

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I like to think he didn't.

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I think I paid my bills on time.

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But what he was prescribing for me could potentially have killed me or put me back in the hospital.

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Because folic acid and multivitamins, in some forms, is actually poison to me.

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So good thing I didn't listen.

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I had to have some dental work done.

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I went to the dentist, and Mr. Dentist says, hey, would you like some nitrous oxide for

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this?

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It will make you feel mellow, make it a little easier for the procedure.

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Sure.

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Sure.

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Give me some nitrous oxide.

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I want to feel mellow.

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I want to enjoy this procedure instead of being in pain.

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So everything goes fine.

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Nothing happened.

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It was great, which is very fortunate, because there are many, many, many documented cases.

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People who did not know that they had some genetic defects that are contraindicated with

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nitrous oxide, and they did not leave the dentist office alive.

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So fortunately for me, I was fine.

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I had a friend who happens to have the same.

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She had the same genetic mutation as I do, and I told her I just went to the dentist.

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Fortunately for me, she was a lot more well-educated in her genetic mutation than I was at the time,

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and she told me, you need to research this.

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You need to really find out, because your doctor is giving you information that really

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is not helpful for you, and there's more that you need to learn.

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So it was clear I needed to learn more about my DNA.

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What is that process like?

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So this is where I jump in.

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So I want to do the same thing.

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So I'm like probably a zillion other people, probably a lot of other folks in this room.

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I wanted to check out one of these commercial genome companies and get my stuff looked

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at, see what I could find out.

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And I'm sure a lot of people have this kind of reasoning behind it as well.

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You can imagine folks that maybe are adopted or maybe think they're adopted or whatever.

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My father's been out of the picture since I was like four.

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I know nothing about his family.

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So I thought, you know, aside from all of the other sort of interesting things, maybe

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there's gaps there.

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There's interesting things there that might be medical-related kind of things that I might

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be able to discover and help fill that gap a little bit.

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So I went and had it done.

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Oh, and let me mention, too, and maybe some of you guys are the same way, also the ancestry

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side, I was kind of like, you know, it would be very cool if I had some sort of hidden

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lineage, right?

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And, you know, I'm part, like, Cherokee.

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Right?

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Or, you know, I have, like, East African descent or something crazy like that, right?

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So I get all this done and I had that there as well.

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And so one of the things, just so you know, and this way I have the picture, is that came

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out of this is that I'm really, really Caucasian.

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And it's, disappointingly, I was disappointingly Caucasian.

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I'm like translucent.

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I'm not entirely sure that you can get any more.

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You know, white European than that.

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And I was truly disappointed.

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But the point I'm trying to make here is that you get all the information from there.

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And it's a pretty good set of information.

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And oftentimes you'll find a little tweak here, a little thing there that you're like,

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oh, you might have this thing or you might be carrying this thing or, you know, there's

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all the ancestry bits.

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But it is very consumer-based, right?

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It's very high level.

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You can, in some cases, dig into things.

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And I very much recommend that.

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But also there's other places you can take that data.

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And that's the purpose here.

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If you look at the stuff above the line here, that's stuff from 23andMe.

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So that's just a snippet of some of my information.

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Super high level, right?

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It's a, hey, variant not detected.

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You know, these items.

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Real easy to read.

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Real easy to consume.

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I get that understanding.

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Nice.

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Side note, you can download all of the SNP data, the raw SNP data.

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And that's where, then you can take that raw SNP data and you can go and plug it into

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other places.

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This one down here is CodeGen.

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CodeGen.

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CodeGen.

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Who knows?

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CodeGen.

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CodeGen.

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So this one down here is just an example of some of the stuff from CodeGen.

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And it gives you an idea, right?

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So the point here is, you see that increased risk of type 2 diabetes?

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That was nowhere in my 23andMe one.

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So different system.

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Different analysis.

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You get some.

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Fill in some gaps.

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It's kind of cool.

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Another thing you might notice with the search.

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Look at the search bar.

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That's searching your SNPs for references to all kinds of things.

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Chemicals, drugs, diseases, and obviously the genes themselves.

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So if you have a specific interest, hey, am I, is there issues with me drinking alcohol?

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Am I predisposed to being an alcoholic?

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That might be an easy way to dig into it.

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Again, the point here is there are some.

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Some simple places.

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Simple ways you can get to more data.

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You can fill your data up.

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I mean, you can fill those gaps a little bit.

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And the nice thing about this one as well.

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You can dig in a little bit more deeply.

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You can drill in.

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And there's many, many more.

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Some of them are free.

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Some of them are not free.

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So what.

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Next.

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What's the moral of the story?

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Moral of the story is information is power.

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Right?

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We all want.

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We want more information.

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The more information you have, the stronger you can be.

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But.

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So.

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Not just that.

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If you know your genetic code.

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If you know your predispositions.

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If I had known mine.

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Perhaps I never would have taken those birth control pills.

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And I wouldn't have ended up in the hospital.

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So if you know ahead of time.

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You're armed.

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Information is power.

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It's also not all.

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Not all information is power.

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Me being the hacker mentality that I have.

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Well, my doctor doesn't really know what I need.

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I know my genetic code now.

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Mostly.

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I'm going to.

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I'm going to fix this.

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So I go on the internet.

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And I look at my genetic code.

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And I look at other people who have contributed information.

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This is what you need to do.

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This is how you get from under-methylating like I am.

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To a normal state.

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So I can repair my DNA.

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I can do all of those good things.

237
00:13:25,720 --> 00:13:26,200
Well.

238
00:13:26,460 --> 00:13:28,280
It didn't work out so well for me there either.

239
00:13:29,000 --> 00:13:31,540
I took all the right form of vitamins.

240
00:13:31,840 --> 00:13:34,160
And one day I'm taking these vitamins.

241
00:13:34,440 --> 00:13:35,720
And I hit the floor.

242
00:13:35,820 --> 00:13:36,440
I pass out.

243
00:13:37,940 --> 00:13:39,700
Me not learning very quickly.

244
00:13:39,820 --> 00:13:41,320
I do it again the next day.

245
00:13:41,420 --> 00:13:42,280
I pass out.

246
00:13:42,280 --> 00:13:44,720
Clearly I need to stop taking these vitamins.

247
00:13:45,020 --> 00:13:45,560
I do.

248
00:13:45,620 --> 00:13:46,260
And everything is fine.

249
00:13:46,560 --> 00:13:47,320
But what happened is.

250
00:13:47,800 --> 00:13:48,940
I changed the balance.

251
00:13:49,040 --> 00:13:49,820
I under-methylated.

252
00:13:50,000 --> 00:13:51,320
And then I over-methylated.

253
00:13:51,520 --> 00:13:52,700
And it was just as bad.

254
00:13:52,940 --> 00:13:55,520
In fact, it was very dangerous.

255
00:13:56,200 --> 00:13:57,600
So don't read everything.

256
00:13:58,020 --> 00:14:00,060
Don't believe everything you read on the internet.

257
00:14:00,320 --> 00:14:01,320
Not because it's wrong.

258
00:14:01,460 --> 00:14:03,180
Because it might be wrong for you.

259
00:14:04,500 --> 00:14:05,260
You need.

260
00:14:05,720 --> 00:14:06,160
Wait.

261
00:14:06,980 --> 00:14:07,780
What did I say?

262
00:14:07,980 --> 00:14:10,420
Did you just say don't believe everything you read on the internet?

263
00:14:10,560 --> 00:14:10,640
No.

264
00:14:10,640 --> 00:14:10,720
No.

265
00:14:10,720 --> 00:14:12,360
Believe everything you read on the internet.

266
00:14:12,420 --> 00:14:12,940
It's all true.

267
00:14:13,180 --> 00:14:13,340
Okay.

268
00:14:13,380 --> 00:14:13,540
Cool.

269
00:14:15,220 --> 00:14:20,220
And so what's important to take here is, yeah, you need to be a steward of your own

270
00:14:20,220 --> 00:14:20,900
health.

271
00:14:21,180 --> 00:14:22,180
You need to be educated.

272
00:14:22,400 --> 00:14:23,160
You need to be knowledgeable.

273
00:14:23,400 --> 00:14:26,420
But you also need to enlist the help of a really good doctor.

274
00:14:26,640 --> 00:14:30,060
One that is interested in helping you based on you.

275
00:14:30,140 --> 00:14:31,400
Not just what is normal.

276
00:14:31,920 --> 00:14:33,760
They're really good at treating sick.

277
00:14:34,180 --> 00:14:37,240
They're not so good at treating you specifically.

278
00:14:37,620 --> 00:14:38,860
But you need to help them.

279
00:14:38,980 --> 00:14:39,960
And if you do that.

280
00:14:40,640 --> 00:14:43,400
You can come to a much better place.

281
00:14:45,440 --> 00:14:51,260
I'll also make the point that the title of the talk is how your doctors are trying to

282
00:14:51,260 --> 00:14:51,620
kill you.

283
00:14:51,900 --> 00:14:53,220
Certainly hyperbole.

284
00:14:53,280 --> 00:14:58,480
The idea there is that you need to be the steward of your own health.

285
00:15:00,320 --> 00:15:03,080
Doctors are there to do that as well.

286
00:15:03,120 --> 00:15:06,940
Some doctors aren't hip to folks trying to help them out.

287
00:15:07,180 --> 00:15:08,040
And maybe that.

288
00:15:08,120 --> 00:15:10,060
And if that's what you're looking for.

289
00:15:10,120 --> 00:15:10,620
Then you need to find a doctor.

290
00:15:10,620 --> 00:15:11,220
You need to find another doctor.

291
00:15:14,320 --> 00:15:16,500
We want to touch on a couple of other things.

292
00:15:17,100 --> 00:15:17,500
Risk.

293
00:15:17,680 --> 00:15:18,700
Man, there are tons of risks.

294
00:15:18,840 --> 00:15:24,860
And I think that this set of things here could be a three-hour panel discussion easily.

295
00:15:25,660 --> 00:15:27,880
All of the ethical concerns.

296
00:15:28,220 --> 00:15:29,340
All of the security risks.

297
00:15:29,460 --> 00:15:29,900
Here's the thing.

298
00:15:31,320 --> 00:15:34,740
This company generated SNP data for me.

299
00:15:35,300 --> 00:15:36,180
They have it.

300
00:15:36,280 --> 00:15:36,900
I have it.

301
00:15:36,940 --> 00:15:37,320
Which is nice.

302
00:15:37,360 --> 00:15:39,240
At least I have control of what I have.

303
00:15:39,240 --> 00:15:40,920
What control do they have?

304
00:15:41,000 --> 00:15:42,480
What are they going to do with it over time?

305
00:15:42,660 --> 00:15:43,760
Who do they share it with?

306
00:15:44,140 --> 00:15:46,360
What happens when they get bought by another company?

307
00:15:46,480 --> 00:15:51,200
What happens when the country that they're incorporated in has a military coup and is

308
00:15:51,200 --> 00:15:52,080
now a fascist country?

309
00:15:53,200 --> 00:15:55,640
All of these questions are significant questions.

310
00:15:55,800 --> 00:15:58,300
And you have to ask yourself what you're comfortable with.

311
00:15:58,500 --> 00:16:01,980
You also have to ask yourself what's the risk versus reward?

312
00:16:02,260 --> 00:16:04,760
Is this going to help me over time?

313
00:16:06,740 --> 00:16:08,440
These are difficult things, I think.

314
00:16:08,440 --> 00:16:13,460
And we're not going to answer those things up here, just to say that we recognize that

315
00:16:13,460 --> 00:16:13,820
they're there.

316
00:16:15,960 --> 00:16:17,540
Is there anything you want to get off this line?

317
00:16:18,460 --> 00:16:21,960
Oh, this is another risk of some sort, right?

318
00:16:23,160 --> 00:16:24,640
Oh, that's not my brother.

319
00:16:25,400 --> 00:16:27,040
Or oh, this guy.

320
00:16:29,800 --> 00:16:31,040
Where did these come from?

321
00:16:31,920 --> 00:16:33,960
Sorry, this is from the 23andMe forums.

322
00:16:34,060 --> 00:16:35,540
This is just from one month alone.

323
00:16:35,860 --> 00:16:38,360
People saying, wow, I have a half-sister I didn't know about.

324
00:16:38,440 --> 00:16:39,620
That's not my dad.

325
00:16:39,740 --> 00:16:40,460
And I thought it was.

326
00:16:40,620 --> 00:16:41,500
I think you have.

327
00:16:41,660 --> 00:16:42,080
Yeah, yeah.

328
00:16:42,160 --> 00:16:46,260
So I have a friend who's a woman, she's in her 70s.

329
00:16:46,540 --> 00:16:49,140
And she went and had this done with Ancestry.

330
00:16:49,520 --> 00:16:53,260
And turns out, her father was not her father.

331
00:16:53,760 --> 00:16:59,780
And I thought to myself, that's an incredible thing to learn at 70.

332
00:17:00,120 --> 00:17:05,760
I mean, that's 70 years of this is who I am, and now that's not who I was.

333
00:17:05,800 --> 00:17:06,380
That's crazy.

334
00:17:06,380 --> 00:17:08,740
And both of her parents have passed away.

335
00:17:08,940 --> 00:17:13,340
And her father, who she never knew was her father, has also passed away.

336
00:17:13,460 --> 00:17:16,280
So there's not much to do there.

337
00:17:16,380 --> 00:17:19,200
But man, what a fantastic and crazy thing to have happened.

338
00:17:21,040 --> 00:17:23,260
So we'll just leave you with some resources.

339
00:17:23,360 --> 00:17:29,040
Again, there are several places that you can take that data and do more with that data.

340
00:17:29,720 --> 00:17:31,300
Live Wello is an interesting one.

341
00:17:31,440 --> 00:17:32,680
That's the one with, oh, NutriHacker.

342
00:17:32,760 --> 00:17:36,240
No, NutriHacker is the one that, wait, which one?

343
00:17:36,240 --> 00:17:37,020
Is it Live Wello?

344
00:17:37,080 --> 00:17:38,840
The one that, like, will guide you through...

345
00:17:38,840 --> 00:17:39,200
NutriHacker.

346
00:17:39,420 --> 00:17:39,860
NutriHacker.

347
00:17:40,100 --> 00:17:45,900
Will guide you through, based on your genetic data, will guide you through, like, life

348
00:17:45,900 --> 00:17:47,200
decisions and...

349
00:17:48,580 --> 00:17:49,540
What to avoid.

350
00:17:49,680 --> 00:17:54,120
Yeah, food choices and drug choices and those kind of things, and give you some guidance

351
00:17:54,120 --> 00:18:02,820
based purely on your DNA, which, you know, keep in mind, that's basing a lot on maybe

352
00:18:02,820 --> 00:18:03,160
a little.

353
00:18:03,240 --> 00:18:05,320
So, you know, use some common sense.

354
00:18:06,240 --> 00:18:10,940
Oh, and then there's even some more deep stuff here, a little deeper.

355
00:18:12,300 --> 00:18:17,340
Yeah, so the previous slide would show you how to get some pretty reports and really

356
00:18:17,340 --> 00:18:19,680
look at things from a higher level, easy to read.

357
00:18:20,700 --> 00:18:22,860
This is if you want to dig deeper.

358
00:18:23,020 --> 00:18:27,300
You can do so much with this set of resources, and this is not comprehensive by any means,

359
00:18:27,420 --> 00:18:33,360
but this can allow you to really dig into the exact research that is involved with each

360
00:18:33,360 --> 00:18:35,080
of the SNPs or in each of your variations.

361
00:18:35,080 --> 00:18:41,880
You can spend months just looking at probably one variation in your genome, but this is

362
00:18:41,880 --> 00:18:42,960
a really good place to start.

363
00:18:43,180 --> 00:18:48,800
Again, not comprehensive, but I encourage you guys to go out and learn about yourself.

364
00:18:50,440 --> 00:18:55,720
Yeah, so I don't know that we're the type that we can answer any questions, but I guess

365
00:18:55,720 --> 00:18:57,200
we could take a question or two if there is any.

366
00:18:57,480 --> 00:18:58,040
Thank you.

367
00:18:59,100 --> 00:18:59,540
Yes.

368
00:19:08,460 --> 00:19:11,140
I'm just curious what the process is for these companies.

369
00:19:12,540 --> 00:19:18,900
What sort of genetic material do you send them for testing, and is it possible to do

370
00:19:18,900 --> 00:19:19,620
it anonymously?

371
00:19:21,360 --> 00:19:22,860
Ooh, anonymously is a good question.

372
00:19:23,400 --> 00:19:24,840
Oh, she must know something.

373
00:19:24,940 --> 00:19:30,820
Yeah, so most of them are basically a spit culture of some sort, and they send you all

374
00:19:30,820 --> 00:19:31,140
the stuff.

375
00:19:31,220 --> 00:19:32,080
They make it super easy.

376
00:19:32,580 --> 00:19:34,380
And you've got to generate at some level.

377
00:19:34,380 --> 00:19:35,320
And you've got to spit into this thing.

378
00:19:35,440 --> 00:19:40,140
And I think it feels like a quart of spit, but it's really not that much.

379
00:19:41,100 --> 00:19:42,600
What were we going to say about the Anonymous?

380
00:19:42,700 --> 00:19:42,900
Oh, yeah.

381
00:19:44,180 --> 00:19:50,360
So when I went into this being a cybersecurity professional, I have concerns about my privacy

382
00:19:50,360 --> 00:19:52,480
tied to my genetic DNA.

383
00:19:53,280 --> 00:19:58,520
I registered as anonymous, but one of the risks is how anonymous is anonymous.

384
00:19:58,860 --> 00:20:03,460
And not only that, but to get the rich information, how much do you have to disclose that you're

385
00:20:03,460 --> 00:20:05,240
voiding that anonymity?

386
00:20:05,340 --> 00:20:08,400
But there are ways to do it anonymously.

387
00:20:09,420 --> 00:20:11,120
You could just build your own lab.

388
00:20:11,280 --> 00:20:14,740
I'm sure we're not that far away from that, I'm hoping.

389
00:20:15,020 --> 00:20:18,320
It is quite expensive now, but everything gets cheaper and cheaper.

390
00:20:18,680 --> 00:20:19,840
So yeah.

391
00:20:20,960 --> 00:20:21,880
If I may?

392
00:20:22,160 --> 00:20:22,560
Yes.

393
00:20:22,620 --> 00:20:29,560
Having been genetically tested, if you're a clever hacker, do you think there are ways

394
00:20:30,140 --> 00:20:33,440
to get the samples, literally, to get the samples?

395
00:20:33,460 --> 00:20:34,740
If you're a clever hacker, do you think there are ways to get the samples, literally, rerouted

396
00:20:34,740 --> 00:20:36,700
through physical relays?

397
00:20:37,400 --> 00:20:41,740
You can use pseudonyms, you can use burner cards.

398
00:20:42,780 --> 00:20:49,460
And you can access things through Tor, etc.

399
00:20:50,160 --> 00:20:54,460
It's just, how anonymous do you really want to be?

400
00:20:54,800 --> 00:20:56,760
Is it worth the hassle?

401
00:20:57,220 --> 00:20:58,220
That sounds like talk.

402
00:20:58,360 --> 00:21:00,140
Yeah, that does sound like a talk.

403
00:21:00,920 --> 00:21:03,080
If you do that talk, I want to be there for that.

404
00:21:05,300 --> 00:21:10,220
I want to know how prevalent are SNPs, single nucleotide polymorphisms?

405
00:21:10,480 --> 00:21:15,560
And also, how much, almost like what's the breadth, how much research is done on each

406
00:21:15,560 --> 00:21:20,660
variation, each occurrence, and what's the odds of what you have actually being something

407
00:21:20,660 --> 00:21:21,120
significant?

408
00:21:21,440 --> 00:21:27,720
To answer that, I want to go with how companies like 23andMe sequence your genetic code.

409
00:21:27,900 --> 00:21:30,640
They don't see everything about you.

410
00:21:30,640 --> 00:21:36,840
There are certain common variations that they test for, and they compare it to your DNA.

411
00:21:37,440 --> 00:21:39,420
And that's where the SNPs come in.

412
00:21:41,840 --> 00:21:43,180
So they're common.

413
00:21:43,660 --> 00:21:44,640
They're very common.

414
00:21:44,740 --> 00:21:50,220
Whether they're expressed or turned on or off is another debate, but they're very common.

415
00:21:50,440 --> 00:21:55,640
In fact, what I said, I have the MTHFR homozygous C677D.

416
00:21:55,860 --> 00:21:57,880
About a third of you probably are the same.

417
00:21:58,000 --> 00:21:59,500
It's pretty common.

418
00:21:59,980 --> 00:22:00,500
Yeah.

419
00:22:01,280 --> 00:22:05,600
And I'll say some of them are, you know, saying you have a mutation or a variant, sometimes

420
00:22:05,600 --> 00:22:07,160
that can sound like something.

421
00:22:07,960 --> 00:22:11,900
Not only is there the issue of expression and epigenetics, but there's also just the fact

422
00:22:11,900 --> 00:22:16,760
that sometimes it's just for something goofy, like I can smell asparagus in people's pee.

423
00:22:17,280 --> 00:22:22,160
So you know, it's nothing to be like, to fret over necessarily.

424
00:22:23,680 --> 00:22:28,120
Veritas Genetics will do your entire genome now for 1,000 U.S.

425
00:22:28,220 --> 00:22:29,140
It's coming down.

426
00:22:29,140 --> 00:22:30,720
Are you thinking of doing that?

427
00:22:30,980 --> 00:22:31,380
Ooh.

428
00:22:31,580 --> 00:22:31,880
I am.

429
00:22:32,160 --> 00:22:32,560
Yeah?

430
00:22:32,800 --> 00:22:33,200
Definitely.

431
00:22:33,440 --> 00:22:34,920
I want to know what I don't know.

432
00:22:35,360 --> 00:22:35,760
Okay.

433
00:22:36,960 --> 00:22:38,320
Plus they're doing a lot.

434
00:22:38,440 --> 00:22:40,560
That's another interesting thing about these companies, too.

435
00:22:40,660 --> 00:22:42,320
Now they have this amazing data set, right?

436
00:22:42,820 --> 00:22:48,140
And they're now doing correlations where they would have never known there was a correlation

437
00:22:48,140 --> 00:22:48,460
before.

438
00:22:48,880 --> 00:22:55,220
And some of it's goofy, but the proof of concept is there, and they're starting to get to the

439
00:22:55,220 --> 00:22:55,880
point where they can say.

440
00:22:56,400 --> 00:22:59,120
Based on previous data that we've seen.

441
00:22:59,120 --> 00:23:05,100
We know that you have a 80% chance of something goofy, like cleft chin or something.

442
00:23:05,880 --> 00:23:06,680
Last question.

443
00:23:08,180 --> 00:23:09,320
So great talk.

444
00:23:09,420 --> 00:23:11,720
Thanks very much for sharing your personal stories.

445
00:23:11,860 --> 00:23:16,660
And one of the challenges of genetics is even if you do all that, you're potentially not

446
00:23:16,660 --> 00:23:18,580
anonymous because we can find you.

447
00:23:19,180 --> 00:23:23,600
It's maybe five to 10 other factors and we'll identify you.

448
00:23:23,860 --> 00:23:28,480
So the law currently says from a medical standpoint in this country.

449
00:23:29,200 --> 00:23:34,300
You cannot be prevented from accessing pre-existing condition.

450
00:23:34,640 --> 00:23:38,080
The challenge is that that's not true from insurance.

451
00:23:39,200 --> 00:23:45,560
And you can be declined insurance as a result of it, which makes what you've done essentially

452
00:23:46,220 --> 00:23:46,980
a risk.

453
00:23:47,160 --> 00:23:47,580
Absolutely.

454
00:23:48,100 --> 00:23:49,940
I've been fully sequenced.

455
00:23:50,080 --> 00:23:51,940
I've had a full genome sequence.

456
00:23:52,020 --> 00:23:55,960
I've had 23andMe as part of an exploration.

457
00:23:56,020 --> 00:23:58,460
And one of the challenges I find with that is that there's a real risk.

458
00:23:58,460 --> 00:24:03,700
There's a real disconnect with the data and the reality of exploring it, certainly when

459
00:24:03,700 --> 00:24:08,120
it got faxed to my general practitioner as a printed report, which was just preposterous

460
00:24:08,120 --> 00:24:08,280
to me.

461
00:24:10,660 --> 00:24:16,800
I'm just curious to know what you think about the impact that that's had on you or has it.

462
00:24:16,920 --> 00:24:20,220
Has that changed anything from your world in terms of...

463
00:24:20,220 --> 00:24:26,820
So I haven't experienced any explicit impact related to insurance coverage and any of those

464
00:24:26,820 --> 00:24:27,200
kind of things.

465
00:24:27,260 --> 00:24:28,360
But that's an interesting question.

466
00:24:28,360 --> 00:24:30,480
That's one of the risks that we may have.

467
00:24:30,560 --> 00:24:32,040
It's one of the things I don't know that we've solved.

468
00:24:32,240 --> 00:24:33,640
I think some people think it's solved.

469
00:24:33,700 --> 00:24:34,900
I don't think it's really solved for sure.

470
00:24:36,020 --> 00:24:41,160
I'm one of the guys that is more willing to be...

471
00:24:41,160 --> 00:24:46,800
I'm more willing to give up more of my privacy to get more stuff out of life.

472
00:24:47,920 --> 00:24:53,600
I know that's contrary to this whole crowd, but I'm kind of like Joe U.S.

473
00:24:53,620 --> 00:24:58,340
I'm, yeah, yeah, here, have some stuff and tell me some stuff and let's see what happens.

474
00:24:58,340 --> 00:25:00,640
Security through obscurity, right?

475
00:25:00,940 --> 00:25:02,600
And I think a lot of people are that way.

476
00:25:02,880 --> 00:25:05,700
And I think that at the end of the day, there's some serious risk there.

477
00:25:07,640 --> 00:25:09,240
I don't know if that answered your question.

478
00:25:09,500 --> 00:25:10,840
I haven't run into anything.

479
00:25:11,040 --> 00:25:12,520
No, I think that's a fair comment.

480
00:25:12,560 --> 00:25:17,680
And ultimately, I think we all give up our privacy at the point that we have a catastrophic

481
00:25:18,050 --> 00:25:19,320
illness or a condition.

482
00:25:19,420 --> 00:25:19,740
Absolutely.

483
00:25:19,740 --> 00:25:21,100
Because at that point, who cares?

484
00:25:21,340 --> 00:25:21,700
Right.

485
00:25:21,740 --> 00:25:22,940
I need all of the information.

486
00:25:23,000 --> 00:25:25,280
So I think it's not an unreasonable...

487
00:25:25,280 --> 00:25:27,980
I don't want anybody to stab me in this circumstance.

488
00:25:27,980 --> 00:25:28,320
But I think that's a fair comment.

489
00:25:28,320 --> 00:25:34,900
But at some point, you've got to give up something to get all of that, and it's finding

490
00:25:34,900 --> 00:25:35,360
the balance.

491
00:25:35,560 --> 00:25:35,920
But thank you.

492
00:25:35,920 --> 00:25:36,180
Agreed.

493
00:25:36,420 --> 00:25:36,780
Nice.

494
00:25:37,140 --> 00:25:37,500
Okay.

495
00:25:37,580 --> 00:25:38,160
I think that's it, folks.

496
00:25:38,240 --> 00:25:39,000
Thank you guys very much.