[00:27.330 --> 00:31.290]  Greetings fellow hackers, biohackers, and
[00:31.290 --> 00:37.690]  friends of Four Thieves Vinegar. This is Michael Laufer, recording for you from a
[00:37.690 --> 00:41.770]  secure undisclosed location. And don't worry, we'll actually have a live Q&A
[00:41.770 --> 00:45.870]  after this session, so I will be available and excited to chat with all
[00:45.870 --> 00:51.770]  of you. I am chief spokesperson for the Four Thieves Vinegar Collective, and I do
[00:51.770 --> 00:56.810]  want to emphasize the fact that we are a collective. Oftentimes it gets forgotten
[00:56.810 --> 01:05.050]  because the many people who do the work for this are in the shadows. They have to,
[01:05.050 --> 01:09.590]  for understandable reasons, keep themselves safe and can't be known to
[01:09.590 --> 01:16.230]  the public. But there are so many people who work on the Four Thieves projects, and
[01:16.230 --> 01:22.070]  there are so many teams who do so much amazing work. And I just want to emphasize
[01:23.050 --> 01:28.130]  that it really does take a village, and when you're going for a project like
[01:28.130 --> 01:33.850]  this it takes a lot of people with a lot of expertise. And I just want to
[01:33.850 --> 01:36.910]  recognize how amazing all of these people that I'm lucky enough to get to
[01:36.910 --> 01:43.070]  work with are. And maybe some of you out there will be inspired to come and help
[01:43.070 --> 01:50.770]  us, because you can always use more people with great talents. So I want to
[01:50.770 --> 01:55.610]  go through and talk about some of the things that we have coming up. I can't
[01:55.610 --> 01:59.210]  talk about all of them, of course. We have about 11 different projects on the
[01:59.210 --> 02:03.030]  boards, but I'd like to talk about three or four of them, and specifically how
[02:03.030 --> 02:10.270]  they connect and relate to our main mission. Our main mission being that we
[02:10.830 --> 02:16.590]  look to develop ways that people can get access to medicines and medical
[02:16.590 --> 02:21.590]  technologies without having to interface with the medical infrastructure, do-it-
[02:21.590 --> 02:28.850]  yourself methodologies, which of course rings with the hacker spirit. First thing
[02:28.850 --> 02:35.810]  I want to chat about is drug delivery methodologies. Now we often sort of
[02:35.810 --> 02:40.630]  forget about this, that somebody says they're taking a drug, or that some
[02:40.630 --> 02:44.410]  medication was administered to them. But the way that drug is administered we
[02:44.410 --> 02:49.930]  sometimes forget. Usually we think about taking pills, but there are so many other
[02:49.930 --> 02:54.790]  ways that a drug can make its way into your body. Oftentimes you'll get an
[02:54.790 --> 02:59.270]  injection, of course. There are different types of injections. We've seen, of
[02:59.270 --> 03:02.350]  course, that there are also different types of pills. There are tablets, and
[03:02.350 --> 03:06.870]  there are capsules, and there are time-release versions, and instantaneous-release
[03:06.870 --> 03:12.950]  versions. Additionally, you see things that are more advanced nowadays. You see
[03:12.950 --> 03:16.250]  things like transdermal patches, of course. Everybody's familiar with nicotine
[03:16.250 --> 03:20.230]  patches, but you see that also with nitroglycerin, other medications that
[03:20.230 --> 03:24.050]  make their way through. Even fentanyl is delivered in a patch for people who have
[03:24.050 --> 03:30.350]  chronic pain. Inhalers, of course. And so looking at some of these images here, I
[03:31.290 --> 03:36.190]  wanted to just take a moment to remember this really fun workshop that we did
[03:36.190 --> 03:41.410]  last year at DEF CON here in Biohack Village, where we were talking about
[03:41.410 --> 03:46.070]  hacking different drug delivery methodologies. And that you see that
[03:46.070 --> 03:50.550]  that's actually, of course, not an inhaler. That's a vape pen. But you can hijack a
[03:50.550 --> 03:54.590]  vape pen to work as an inhaler. And there are certain things that make their way
[03:54.590 --> 03:58.250]  into your body more efficiently through the lungs than they do through other
[03:58.370 --> 04:03.110]  means. Transdermal patches, when you buy them off the shelf, of course, are
[04:03.110 --> 04:08.170]  made with these specialized gelatins. But you can make them yourself using gauze
[04:08.170 --> 04:14.910]  pads and DMSO and some saran wrap and some medical tape. These things are all
[04:14.910 --> 04:19.890]  hackable. But these aren't the ones I wanted to talk about. There's a different
[04:19.890 --> 04:26.670]  one that is very exciting. So take a moment and see if this looks familiar to
[04:26.670 --> 04:35.570]  you at all in any regard. What you're looking at here is a cylindrical piece of
[04:35.570 --> 04:42.530]  flexible plastic. And what it is, it is a piece of plastic, which is
[04:42.530 --> 04:48.370]  biocompatible. And it's doped with the active pharmaceutical ingredient, which
[04:48.370 --> 04:53.290]  needs to be put into a person's body. Now, I'm sure some of you have heard of
[04:53.290 --> 04:58.690]  this before. In the 90s, the first generation of this was called Norplant.
[04:58.690 --> 05:04.490]  And it was a birth control drug. It's placed in the upper arm and you can see
[05:05.070 --> 05:14.510]  the more modern version that's called Nexoplanon. And it's being inserted with
[05:14.730 --> 05:19.750]  a hollow needle here in the upper arm of someone you can see in the upper right
[05:19.750 --> 05:24.970]  hand corner. Now, for those of you who are not familiar with this, or just
[05:24.970 --> 05:30.170]  seeing it for the first time, and those of you who've seen it before, take a
[05:30.170 --> 05:36.670]  moment to just look and see if this reminds you of anything. And let that
[05:36.670 --> 05:41.070]  percolate in your brain while we move on. Now, the question is, of course, how is
[05:41.070 --> 05:48.490]  this made? And how do you use it? Now, the uses are incredibly widespread. Now,
[05:48.490 --> 05:54.290]  it's been already used for birth control. And it's currently being tested. I
[05:54.290 --> 05:57.970]  believe it's in phase 2A trials for pre-exposure prophylaxis, which is really
[05:57.970 --> 06:02.290]  huge. You think about something that could be put under your skin, that could
[06:02.290 --> 06:09.110]  protect you from HIV infection for a decade. That's extraordinarily powerful.
[06:09.110 --> 06:15.570]  And this really applies to anything that is something that anybody has to take
[06:15.570 --> 06:23.830]  regularly, and where adherence is a big problem. Sovaldi is arguably the most
[06:23.830 --> 06:28.970]  incredible thing that's ever been put out by the pharmaceutical industry. It
[06:28.970 --> 06:35.090]  literally cures hepatitis C in 12 weeks. The problem is, is that if you do not
[06:35.090 --> 06:41.810]  take that pill every day, in the same way, at the same time, and you fall off
[06:42.530 --> 06:48.090]  adherence, it doesn't take and then you have to start over. And that's an $82,000
[06:48.090 --> 06:54.850]  treatment. It shouldn't be and needn't be for reasons that you all know. But of
[06:54.850 --> 07:00.450]  course, it's tragic when you get it together to get treatment to somebody and
[07:00.450 --> 07:08.510]  it doesn't happen because somebody just forgot a dose one day. If this could
[07:08.510 --> 07:11.630]  instead be put into an implant, and somebody could get it put under their
[07:11.630 --> 07:17.590]  skin and 12 weeks later gets taken out and their hepatitis C free, that would
[07:17.590 --> 07:23.550]  solve that particular problem, then you'd get 100% adherence instead of only
[07:23.550 --> 07:30.790]  40%. Again, looking at all manner of things, if you think for a moment about
[07:31.550 --> 07:39.290]  whether you or anybody who know, has any medication that they take every day, why
[07:39.950 --> 07:45.650]  take the time and the attention to take it every day when you could merely have
[07:45.650 --> 07:49.510]  something put under your skin and it would just sit there and you wouldn't
[07:49.510 --> 07:56.350]  have to worry about that autoimmune issues. Hormone replacement therapy is
[07:56.350 --> 08:02.390]  one that I'm very excited about. I know so many trans people who are so worried
[08:02.390 --> 08:10.770]  about having their pipeline interrupted. And if we could instead place hormones
[08:10.770 --> 08:14.850]  in an implant, which we know is possible because it was done with birth control
[08:14.850 --> 08:20.130]  and say, hey, you don't have to worry about taking your shots or interface with
[08:20.130 --> 08:25.870]  the medical infrastructure for five, maybe 10 years at a time. I think that
[08:25.870 --> 08:31.850]  would solve a lot of really amazing problems. The naloxone pro drug that we
[08:31.850 --> 08:34.890]  were looking at a couple of years ago would be really great to be able to put
[08:34.890 --> 08:41.230]  into this. This would essentially be an overdose safeguard antidote that you
[08:41.230 --> 08:45.550]  could put under somebody's skin and they wouldn't overdose. I mean, amazing.
[08:45.550 --> 08:53.150]  Even things as basic as vitamins. Most people are vitamin B deficient. And you
[08:53.150 --> 08:57.170]  could just have a vitamin B complex implant that would continue to dose your
[08:57.170 --> 09:05.730]  body with vitamin B around the clock for years. And again, anything where people
[09:05.730 --> 09:12.610]  have to take something every day. If you know anybody over the age of 60 in the
[09:12.610 --> 09:16.050]  United States, they have several medications typically that they take
[09:16.050 --> 09:24.330]  every day. And again, as years go on and days blur together, it can be harder and
[09:24.330 --> 09:29.650]  harder to remember to take something at the same time every day. And that takes
[09:29.650 --> 09:33.950]  care of that particular problem. So it's a very exciting technology in general.
[09:33.950 --> 09:39.650]  Of course, the question is, you know, how do we hijack it? How is it made? So the
[09:39.650 --> 09:46.210]  plastic has to actually be extruded. And so you have this big industrial machine
[09:46.790 --> 09:51.170]  that's full of the active pharmaceutical ingredient as well as the plastic and
[09:51.170 --> 10:00.430]  then it's pushed down through this screw and then heated along the way. And it's
[10:00.430 --> 10:05.670]  pressed out a dye. Here's a diagram that sort of shows that and you can see the
[10:05.670 --> 10:11.030]  spot there where everything's put into the feeder and that's the pharmaceutical
[10:11.030 --> 10:17.350]  ingredient along with the plastic. The plastic is usually PLA or PLA and
[10:17.350 --> 10:24.210]  another plastic. Again, some of you will start to see where this is heading. And
[10:24.210 --> 10:29.570]  it gets pressed out a dye at the end and then you get these little pieces of
[10:29.570 --> 10:35.230]  filament which are then broken off. And the question is, well, how do we do that?
[10:35.230 --> 10:43.970]  Well, this is the same as the 3D printing filament that is made by
[10:43.970 --> 10:49.690]  hobbyists all over the world. People who are enthusiasts of 3D printing, of
[10:49.690 --> 10:54.490]  course, take their old failed prints, shred them up, and re-extrude them. And
[10:54.490 --> 10:59.070]  if you can look at the image on the right, you can, of course, get ones that
[10:59.070 --> 11:04.350]  are manufactured in such a way that they're kind of a commercial. There are
[11:04.350 --> 11:07.830]  the kits like the filler extruder in the upper right and there are ones that are
[11:07.830 --> 11:15.030]  home-built like on the lower right. And this is basically all it takes. Concerns,
[11:15.030 --> 11:18.490]  of course, of trying to make sure the densities are homogenous and you don't
[11:18.490 --> 11:20.930]  get the active pharmaceutical ingredients separating away from the
[11:20.930 --> 11:25.450]  plastic is simple to fix at a small scale. You merely extrude the plastic,
[11:25.450 --> 11:31.410]  shred it again, and then re-extrude. And eventually you can have something where
[11:31.410 --> 11:36.990]  you merely load it into the same sort of thing that you use to plant an RFID
[11:36.990 --> 11:45.730]  implant into your hand and be able to put these in however you need them. Now,
[11:45.730 --> 11:52.230]  of course, the natural question that comes up is, well, then what do you do
[11:52.230 --> 11:56.470]  about getting the active pharmaceutical ingredient? And, of course, there are ways
[11:56.470 --> 12:01.590]  to source those in some cases. But one of the big things that we've been focusing
[12:01.590 --> 12:07.890]  on for a very long time is how do you manufacture your own drugs? And so I'm
[12:07.890 --> 12:13.010]  very excited to present to all of you the new Apothecary Microlab. And this is
[12:13.370 --> 12:20.170]  a picture of me holding the 3D printed case that has the brains of the machine
[12:20.170 --> 12:25.690]  in it. And you can see at the top there, there's the embossed logo and there's
[12:25.690 --> 12:37.270]  the touchscreen interface. And inside you have a Raspberry Pi and a shield that
[12:37.270 --> 12:41.570]  sits on top of that with relays. And it is connected then also to an Arduino
[12:41.570 --> 12:51.630]  which has a CNC shield on top of it. And I'll show you a little diagram for each
[12:51.630 --> 12:56.070]  of those sub-assemblies. Here's the Raspberry Pi and the relay board and
[12:56.070 --> 13:02.790]  then the touchscreen interface. And then this is a separate part, the CNC
[13:02.790 --> 13:12.070]  shield that sits on top of the Arduino. Arduino sends over G-code then sends
[13:12.070 --> 13:18.510]  information. So I put this together because the part of this graphic was
[13:18.510 --> 13:22.850]  actually put together by some yellow journalists who were trying to shame us
[13:22.850 --> 13:28.130]  when I was quoted as saying, shouldn't be any harder than putting together IKEA
[13:28.130 --> 13:33.930]  furniture to build the micro lab. And at this point, it really isn't. And the
[13:33.930 --> 13:38.590]  hardware team has done a just spectacular job of coming together with
[13:39.570 --> 13:44.290]  finding parts that are literally off the shelf. No manufacturing required and no
[13:44.290 --> 13:48.670]  soldering required. These literally snap together, which is so cool. It really
[13:48.670 --> 13:52.430]  means that anybody could build it. And here's a little diagram of how
[13:52.430 --> 13:58.110]  everything's connected. Those are stepper motors that drive the syringe pumps. And
[13:58.110 --> 14:03.670]  also that drive the stirring motor. And there's a sensor with the heat
[14:03.670 --> 14:11.770]  thermocouple and all bits and pieces. What you're looking at here is a video
[14:11.770 --> 14:21.130]  in real time of the head of the hardware team actually assembling the entire
[14:21.130 --> 14:25.710]  micro lab. And in addition to the fact that this is happening real time, what
[14:25.710 --> 14:33.650]  you see on the table here as he's working is everything that is required.
[14:33.890 --> 14:37.490]  And including the tools, I guess it's just slightly out of frame, but his
[14:37.490 --> 14:44.030]  three tools are a hex key, a small screwdriver, and a pair of scissors. And
[14:44.030 --> 14:50.230]  using nothing else, it takes him about 25 minutes to assemble this. So it
[14:50.230 --> 14:55.610]  probably won't finish quite by the time I'm done. But hopefully if the editing
[14:55.610 --> 15:00.070]  goes well, what will occur here is that as I go to the next slide, this video
[15:00.070 --> 15:05.990]  will go into a corner and you'll be able to see it continue in real time as I
[15:05.990 --> 15:12.210]  continue to talk about some of the other stuff that we've been working on. So you
[15:12.210 --> 15:16.170]  see these 3D printed parts that he's bolting onto the stepper motors. Those
[15:16.170 --> 15:21.150]  are the syringe pumps. The electronics that he snapped together just a moment
[15:21.150 --> 15:27.250]  ago was the control module that I talked about. And the circular piece
[15:27.250 --> 15:32.270]  that's 3D printed on the lower right of the screen that you see is the core for
[15:32.270 --> 15:36.950]  the actual reaction chamber. And then you see some miscellaneous parts along the
[15:36.950 --> 15:43.230]  left side of the screen tubing, the fish pumps that circulate the water, along
[15:43.230 --> 15:51.610]  with the bars and the threaded rod that allows the syringe pumps to work. So
[15:51.610 --> 15:57.330]  hopefully this will now move into the corner and you'll be able to continue to
[15:57.330 --> 16:05.670]  watch it while I talk about the other developments. Now, of course, the big
[16:05.670 --> 16:12.570]  question always is the chemistry. And this is where our chemistry team has
[16:12.570 --> 16:19.490]  done such great work in the past of trying to find ways to synthesize, to
[16:19.490 --> 16:23.430]  actually manufacture the active pharmaceutical ingredients from things
[16:23.430 --> 16:34.510]  that were easily available, cheap, having high margins for error, having no
[16:34.510 --> 16:40.590]  specialized materials needed or specialized techniques used. This was
[16:41.510 --> 16:47.930]  fairly tricky. And some of you, I'm sure, remember that in the early days, we had
[16:48.090 --> 16:52.070]  a deal with a company called Comatica that had developed some very
[16:52.070 --> 16:56.770]  sophisticated machine learning algorithms that would crawl through the
[16:57.610 --> 17:04.250]  databases of chemistry and give good guesses as to what might or might not
[17:04.250 --> 17:08.950]  work in terms of trying to do retrosynthesis on chemistry. Now, they,
[17:08.950 --> 17:15.790]  of course, were bought by Merck and that process is now proprietary, used
[17:15.790 --> 17:20.070]  internally, they don't farm it out, they don't share it. And one thing that we
[17:20.910 --> 17:27.330]  had this idea to do was to say, gosh, you know, we have a data science team,
[17:27.330 --> 17:31.070]  and they looked at some things and they said, you know, we could probably do the
[17:31.070 --> 17:35.110]  same thing, it wouldn't be that hard. And if you look on the right, this is the
[17:35.110 --> 17:39.390]  the NIST database that we had used with only 1000 reactions. And of course, it
[17:39.390 --> 17:45.290]  had the same structure. But Reaxis, the one that Comatica used, which is premium
[17:45.290 --> 17:50.350]  and paid for, of course, has 6 million reactions. Well, some of you remember
[17:50.350 --> 17:56.610]  the narrative and one thing and another, we got our hands on that data. And we're
[17:56.610 --> 18:04.050]  able to actually run an analog of that software. Now, the problem is, is you
[18:04.050 --> 18:10.150]  need a supercomputer for this. A very congenial fellow was working with me, and
[18:10.150 --> 18:15.230]  he tried to put together a Raspberry Pi cluster. And then when he looked at the
[18:15.230 --> 18:19.470]  software, the data science team had passed along, he said, Oh, this isn't
[18:19.470 --> 18:23.950]  going to work. And I asked why. And he said, Well, this is not something that
[18:23.950 --> 18:27.690]  lends itself to parallel computing, you need a traditional supercomputer, you
[18:27.690 --> 18:34.310]  need something with a tremendous amount of RAM, and you need a lot of cores
[18:34.310 --> 18:39.050]  running. And so when you need a supercomputer, the regular thing that
[18:39.050 --> 18:44.750]  most people will suggest is using Google Cloud. And I have some opinions on that.
[18:44.750 --> 18:49.590]  And then other people will suggest using Amazon Web Services. And I have feelings
[18:49.590 --> 18:54.290]  about that too, which I'm sure most of you share. And so the question is, if you
[18:54.290 --> 18:58.850]  need a supercomputer, and you don't want to play ball and pay for it, what do you
[18:58.850 --> 19:08.470]  do? Well, we figured out a solution to this. And we got very lucky. This is the
[19:08.470 --> 19:16.130]  Glitter supercomputer. And it's an HP ProLiant DL580. It's a 4U rack mount
[19:16.130 --> 19:26.590]  unit. And it's extremely powerful. If you look at the specs, this is a 40 core
[19:27.290 --> 19:36.550]  unit with half a terabyte of RAM. It's optimized in a lot of ways, it draws a
[19:36.550 --> 19:44.370]  tremendous amount of power. But we were very lucky that we managed to find one
[19:44.370 --> 19:53.290]  used for $300. Usually these go for upwards of $6,000. I mean, I think that's
[19:53.290 --> 19:57.850]  what the baseline unit costs. And I think it's more like, you know, double that for
[19:57.850 --> 20:01.810]  something with the specs that we have. But we just got very lucky that we found a
[20:01.810 --> 20:06.190]  used one that some company just wasn't using and managed to get our hands on it.
[20:06.190 --> 20:13.890]  In addition to running the software, we're hoping that this can actually
[20:13.890 --> 20:20.570]  become an open source supercomputer that everybody in the hacker community can
[20:20.570 --> 20:24.310]  use. So if somebody has something that they want to run, and they need a
[20:24.310 --> 20:29.630]  supercomputer for it, that they can just use some time on the supercomputer. So
[20:29.630 --> 20:37.690]  I'm gonna try and pull it up here. This is sort of what it'll look like. These
[20:37.690 --> 20:42.630]  are sort of mockups, but just so you can get sort of a sense of what things
[20:42.630 --> 20:49.270]  should look like when the machine is booting and running. Just wanted to give
[20:49.270 --> 20:54.390]  you guys a sense. And of course, you know, you want things to look pretty while
[20:54.390 --> 20:59.230]  they're starting. So if you'll bear with me here. Alright, so this is sort of what
[20:59.230 --> 21:05.930]  the should look like when you start things up. And when it says the smile
[21:05.930 --> 21:13.510]  string smiles is a it's a protocol for being able to use essentially ASCII to
[21:13.510 --> 21:18.910]  input the structure of molecule. And you'll see this looks a little goofy.
[21:19.170 --> 21:23.650]  But at the same time, you can see it's sort of suggested of of the structure of
[21:23.650 --> 21:29.970]  molecule that, of course, is a double bonded O. And here you have, again,
[21:30.590 --> 21:35.670]  another group that's specified and where it is. And this is all standardized in
[21:35.670 --> 21:41.370]  databases. So it's it's good, and it's easy to use. And if this is all work,
[21:41.370 --> 21:49.730]  then this should be go there. And you'll see the computer come up here now with
[21:49.730 --> 21:57.410]  recommendations. And along the right column, you'll see how likely it is that
[21:57.410 --> 22:04.890]  this is actually going to be plausible. And point 999, of course, is is really
[22:04.890 --> 22:08.250]  good. When you see the one that means they are actually found it in the
[22:08.250 --> 22:12.130]  literature. 994 may seem like it's pretty good. But again, this is fairly
[22:12.130 --> 22:15.950]  iffy. The thing that's important to remember when looking at this sort of
[22:15.950 --> 22:21.770]  thing is that the really great strength of machine learning and AI is not to
[22:21.770 --> 22:27.390]  replace human intuition, but to augment it. So this is something that could
[22:27.390 --> 22:35.810]  change things so that instead of needing, say, oh, months to years with a
[22:35.810 --> 22:42.670]  team of really gifted chemists, you could have this with a good chemist, and
[22:42.670 --> 22:47.190]  just one of them and be able to do it in a few days. When you see these things
[22:47.190 --> 22:52.930]  that say cannot buy, that's part of one of the kinks we're working out is, you
[22:52.930 --> 22:56.370]  know, trying to show what's available commercially. And if something isn't
[22:56.370 --> 22:59.450]  available commercially, you'll notice that each of these are, of course,
[22:59.450 --> 23:03.630]  hyperlinks. And what you can do is you can actually click on them and then do
[23:03.630 --> 23:08.410]  the retrosynthesis on one of those and work your way back to see, do you have
[23:08.410 --> 23:12.590]  to make the thing that you need to make the next thing? And again, what is
[23:12.590 --> 23:20.790]  purity and yield look like and how you work forward from there? So to sort of
[23:20.790 --> 23:28.790]  sum up as we're going, you look for treating yourself. When you look for
[23:28.790 --> 23:37.630]  taking control of your own health, the thing to do, of course, is at the end is
[23:37.630 --> 23:41.510]  you need to package your treatment, right? You need that delivery mechanism,
[23:41.510 --> 23:44.710]  whether it's something that you load into a syringe or something that you
[23:44.710 --> 23:50.250]  pack into a tablet, or something to load into an inhaler, you need to package it.
[23:50.250 --> 23:55.390]  But of course, before that, you need to manufacture it, you need to generate that
[23:55.390 --> 24:02.190]  active pharmaceutical ingredient, somehow. And again, the packaging, we
[24:02.190 --> 24:08.730]  have these ideas for specifically, we're trying to develop these, these implants,
[24:08.730 --> 24:12.970]  which is really exciting. The manufacturer, we're hoping to make happen
[24:12.970 --> 24:17.870]  with the new version of the micro lab. And of course, developing a process for
[24:17.870 --> 24:22.890]  manufacture, we're hoping to do with the glitter computer and chemhactica, the new
[24:22.890 --> 24:28.390]  system for trying to do retrosynthesis. But there's one extra piece, which of
[24:28.390 --> 24:33.250]  course, before all of that, having all these things at your fingertips means
[24:33.250 --> 24:42.190]  almost nothing. If you don't know what it is you actually need to manufacture.
[24:42.710 --> 24:48.430]  This is sort of the antecedent problem that comes before everything. And the
[24:48.430 --> 24:53.270]  question comes, of course, how do you determine what it is you need? We all
[24:53.270 --> 25:00.210]  have health issues, but going from I understand what's wrong, or I understand
[25:00.210 --> 25:05.990]  what is not right, I recognize my symptoms, to understanding what is ailing
[25:05.990 --> 25:12.310]  you and what would ameliorate that is quite a jump. So I'm very excited to
[25:12.310 --> 25:16.410]  announce this that we're working on. This is the anarchist medical book, and
[25:16.410 --> 25:22.130]  we're trying to develop a compendium that will be a reference that people can
[25:22.130 --> 25:31.410]  use when they are not well, and yet do not wish to interface with the medical
[25:31.410 --> 25:35.750]  infrastructure. We're really excited. We have a bunch of things that are going
[25:35.750 --> 25:41.930]  into this book. And of course, to all of you out there, if you have things that
[25:41.930 --> 25:46.890]  you think should be included about this, if you know some cool trick, or some
[25:46.890 --> 25:52.930]  secret, some treatment that is not popular, that very few people know about,
[25:52.930 --> 25:57.130]  that other people could benefit from, please, please, please get in touch and
[25:57.130 --> 26:01.290]  let us know about it so that we can include it. We're trying to make this the
[26:01.290 --> 26:06.230]  best book we can, and try to include as much as we can gather. And so all the
[26:06.230 --> 26:10.630]  secret little folk wisdom of all the wonderful hacker anarchist communities
[26:10.630 --> 26:15.190]  out there, we'd really love to pack it in. So please send us anything you can. We'd
[26:15.190 --> 26:22.390]  love to see all of it. This is about where I end. And I always end with this
[26:22.390 --> 26:28.690]  slide. Because it's a, it's an important reminder that that helps not on the way
[26:29.510 --> 26:39.790]  that we really need to work to help each other, keep each other safe. And there's
[26:39.790 --> 26:47.170]  nobody but us. So let's take care of each other. Thank you all so much. It's
[26:47.170 --> 26:51.930]  been wonderful being with you. And after this video closes out, we'll have a
[26:51.930 --> 27:01.520]  little q&a. And I look forward to talking with all of you. Thanks so much.
[27:01.920 --> 27:12.280]  Rest in peace. Here's another warrior song. Here's a toast to the dead for
[27:12.280 --> 27:16.260]  children with cancer and AIDS. A cure exists and you probably could have been
[27:16.260 --> 27:21.060]  saved. Sad to see medicine divorce morality. Corporate homewreckers pipping
[27:21.060 --> 27:22.200]  up the salary.